Nov 19, 2019 · In their Review, Barata, Durum and Seddon describe IL-7’s key homeostatic functions and how its dysregulation can lead to autoinflammatory disease and cancer.

Jun 1, 2002 · IL-7 can be identified within the thymus of 13-day murine embryos coincident with the first wave of thymocyte expansion.19 The production of IL-7 has been identified in a …

Dec 1, 2021 · Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B cells, remains one of the most extensively studied cytokines. It ...

Overview: IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind Type I cytokine receptors. It is produced by stromal cells and is required for development and …

In this review, we focus on the emerging details on the developmentally regulated spatial distribution of IL-7 in vivo that controls all IL-7 receptor (IL-7R) expressing cell subsets with …

Apr 21, 2011 · Interleukin-7 (IL-7) induces T cell proliferation and enhances antigen-specific immune responses: attributes that pinpoint its value as a potential therapeutic agent.

Interleukin-7 (IL-7) is a non-hematopoietic cell-derived cytokine with a central role in the adaptive immune system. It promotes lymphocyte development in the thymus and maintains survival of …

Dec 1, 2022 · IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind Type I cytokine receptors. It is produced by stromal cells and is required for development and …

Dec 1, 2022 · IL-7, originally termed “lymphopoietin-1” (LP-1), was first identified as a pre-B-cell growth factor produced by bone marrow stromal cells [63], [64]. Further studies identified …

IL-7’s essential properties as a required factor for lymphocyte development and modulator of T cell homeostasis make it an attractive candidate for modulating immunodeficiency and …