Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. [3] [4] Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: after removal of the signal peptide sequence, the mature protein contains 133 amino acids in its polypeptide ...

2024年6月12日 · IL-3 plays an important role in bones by directly targeting both osteoblasts and osteoclasts. IL-3 promotes the differentiation of human mesenchymal stem cells into osteoblasts and stimulates the formation and the survival of mononuclear osteoclasts .

The interleukin-3 receptor is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system. The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.

2024年12月25日 · antibodies-online: Show 74 available IL-3 Proteins ranked by validation data; Compare Top IL-3 Proteins

2025年1月6日 · Interleukin-3 (IL-3) is a pleiotropic cytokine with pivotal effects on the regulation of hematopoiesis and immune responses. It is produced mainly by activated T cells and mast cells and acts significantly on the growth and differentiation of several lineages of

2021年7月1日 · Interleukin-3 (IL-3) is a cytokine belonging to the family of common β (βc) and is involved in various biological systems. Its activity is mediated by the interaction with its receptor (IL-3R), a heterodimer composed of two distinct subunits: IL-3Rα and βc.

Interleukin 3 (IL-3), also called multi-CSF, is a cytokine that regulates hematopoiesis. It is produced by T cells and mast cells, after activation with mitogens or antigens. It stimulates eosinophils and B cell differentiation while it inhibits LAK cell activity.

Interleukin-3 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-3 is a type of cytokine. Also called IL-3.

Here, we review the function of IL-3 in health and disease. We describe the cell-specific effects of IL-3 and summarize its role in host defense, autoimmunity, and cancer. Likewise, we discuss the current treatments targeting IL-3 or its receptor and highlight the potential and the limitations of targeting IL-3 in clinics. Cellular targets of ...

Otsuka T, Miyajima A, Brown N, Otsu K, Abrams J, Saeland S, Caux C, de Waal Malefijt R, de Vries J, Meyerson P, et al.: Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones.