Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene. [ 5 ] [ 6 ] [ 7 ] This protein is a member of Ikaros family of transcription factors. [ 8 ]

2024年12月25日 · IKZF2 (IKAROS Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with IKZF2 include Otitis Media and Leukemia, Acute Lymphoblastic . Gene Ontology (GO) annotations related to this gene include nucleic acid …

2025年2月8日 · Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation. Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity.

This study, based on a large clinical cohort, found that IKZF2, an essential transcription factor during T cell development and differentiation, showed stage-dependent overexpression in the malignant T cells in mycosis fungoides lesions.

2023年4月10日 · Degradation of IKZF2 and CK1α blocks cell growth and induces myeloid differentiation in AML cells through CK1α-p53- and IKZF2-dependent pathways. Target degradation by DEG-35 or a more soluble analog, DEG-77, delays leukemia progression in murine and human AML mouse models.

2019年1月3日 · IKZF2 is highly expressed in leukemic stem cells (LSCs), and its deficiency results in defective LSC function. IKZF2 depletion in acute myeloid leukemia (AML) cells reduced colony formation, increased differentiation and apoptosis, and delayed leukemogenesis.

2022年11月15日 · To determine the contribution of CK1α and IKZF2 to the cellular phenotypes in MOLM13 cells, we developed CK1α and IKZF2 nondegradable mutants. CK1α, G40N was able to significantly reduce the cell killing activity of DEG-35 by 94% compared to vector cells (**p<0.01).

2024年12月10日 · Title: Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity.

2019年10月15日 · Terminal Effector CD8 T Cells Defined by an IKZF2 + IL-7R-Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity

2023年3月16日 · Malignant tumors can evade destruction by the immune system by attracting immune-suppressive regulatory T cells (Treg) cells. The IKZF2 (Helios) transcription factor plays a crucial role in maintaining function and stability of Treg …