IKK - 百度百科
IKK（inhibitor of kappa B kinase, kappa B 抑制因子激酶）参与胞内多种细胞信号转导途径，包括由细胞因子引起的细胞凋亡,其中最为人熟知的是可以通过磷酸化细胞质基质中与NF-κB【p65-p50二元复合体蛋白】结合的IκBα蛋白，使其得以被E3泛素连接酶特异性识别并添加 ...
Phospho-IKKα/β (Ser176/180) (16A6) Rabbit mAb #2697
Phospho-IKKα/β (Ser176/180) (16A6) Rabbit mAb detects IKKα only when phosphorylated at Ser176/180 and IKKβ only when phosphorylated at Ser177/181. The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST.
IKKβ Antibody #2684 - Cell Signaling Technology (CST)
IKKβ Antibody detects endogenous levels of total IKKβ protein. The antibody does not cross-react with endogenous levels of IKKα or IKKγ. Human, Monkey. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues at …
Defective kinase activity of IKKα leads to combined ... - Nature
2024年11月16日 · IKKα is a multifunctional serine/threonine kinase that controls various biological processes, either dependent on or independent of its kinase activity. However, the...
IKKa antibody (mAb) (Clone 14A231) | Proteintech | 武汉三鹰生物 …
IKKa (IkB Kinase alpha subunit) – The IkB Kinase (IKK) complex is the key enzyme involved in the activation and translocation of NFkB (NFkB p50 & NFkB p65). The IKK complex is composed of two catalytic subunits (IKKa and IKKb) and a regulatory subunit (IKKg).
IFA analysis of NF-B localization in WT, IKK-/-, IKK ... - ResearchGate
Activation of NF-kappaB by the intracellular pathogen Toxoplasma gondii is associated with the localization of phosphorylated IkappaB alpha to the parasitophorous vacuole membrane (PVM). This is...
核因子κB（nuclear factor kappa-B，NF-κB） - 知乎专栏
受体蛋白接受刺激后先活化IκB激酶（IKK）。 IKK将细胞内NF-κB·IκB复合物的IκB亚基调节位点的丝氨酸磷酸化，使得IκB亚基被泛素化修饰，进而被蛋白酶降解，从而释放NF-κB二聚体。 自由的NF-κB会进入细胞核，与有NF-κB结合位点的基因结合，启动转录进程。 NF-κB也会激活IκBα基因的表达，新合成的IκBα重新抑制NF-κB的活性，从而形成了自发负反馈环，这样的设计原理将形成NF-κB振荡的现象。 核因子κB（nuclear factor kappa-B，NF-κB）蛋白最早由David Baltimore …
Anti-IKK alpha (phospho S176 + S180)抗体(ab17943) - Abcam中 …
Due to sequence homology between the isoforms, this antibody may cross-react with IKKbeta that contains phosphorylated serine 176 and 180. However, we have no direct experimental evidence for this in our records. Synthetic peptide corresponding to IKK alpha (phospho S176 + S180).
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IKKα (3G12) Mouse mAb #11930 - Cell Signaling Technology (CST)
IKKα (3G12) Mouse mAb recognizes endogenous levels of total IKKα protein. Human, Monkey. Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to a carboxy-terminal fragment of human IKKα protein.
IκB kinase - Wikipedia
IκB kinase activity is essential for activation of members of the nuclear factor-kB (NF-κB) family of transcription factors, which play a fundamental role in lymphocyte immunoregulation. [6][8] Activation of the canonical, or classical, NF-κB pathway begins in response to stimulation by various pro-inflammatory stimuli, including lipopolysacchar...