It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin.

2024年3月12日 · What Is Glomerular Filtration Rate? The glomerular filtration rate (GFR) is a measure of how well your kidneys are removing waste from your blood, which can be determined using an...

Enjoying life amongst Rotarians while playing golf on the most exclusive golf courses on the globe! There is nothing better! IGFR was founded at the birthplace of golf, at St Andrews Scotland, in 1964. She has spread her wings over Australia, Europe and North America and is now exploring the continent of Africa, Asia and South America. Loading...

IGF-1 is a hormone found naturally in your blood. Its main job is to manage the effects of growth hormone (GH) in your body. Normal IGF-1 and GH functions include tissue and bone growth. IGF-1 is formed in different tissues as a result of GH in the blood.

Insulin-like growth factor 1 (commonly referred to as IGF-1 or at times using Roman numerals as IGF-I) is mainly secreted by the liver as a result of stimulation by growth hormone (GH). IGF-1 is important for both the regulation of normal physiology, as well as a number of pathological states, including cancer.

2022年7月13日 · Learn about eGFR, how your kidneys filter waste, and why early detection of CKD is crucial for protecting kidney health. Your kidneys filter your blood by removing waste and extra water to make urine. The glomerular filtration …

2021年7月30日 · IGF-1, also known as insulin-like growth factor 1, is a complex and interesting hormone. Is IGF-1 good or bad when it comes to your health? It has the potential to have both effects depending on how much your body produces. Its most important job is to promote cell growth (hence the name).

The growth hormone–insulin-like growth factor–insulin-like growth factor binding protein (GH–IGF–IGFBP) axis plays a critical role in the maintenance of normal renal function and the pathogenesis and progression of chronic kidney disease (CKD).

Insulin and insulin-like growth factor (IGF) signaling system, commonly known for fine-tuning numerous biological processes, has lately made its mark as a much sought-after therapeutic targets for diabetes and cancer.

Results: Our results indicate that a reduction in IGF-1 receptor (IGFR) expression with age is associated with decline in hippocampal-dependent learning and increased gliosis. Astrocyte-specific knockout of IGFR also induced impairments in working memory.