Dec 25, 2024 · Complete information for IGFL1 gene (Protein Coding), IGF Like Family Member 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Jan 28, 2022 · 近期，高分肿瘤学主流期刊《Cancer Letters》在线发表了题为“KLF5-induced lncRNA IGFL2-AS1 promotes basal-like breast cancer cell growth and survival by upregulating the expression of IGFL1”的研究论文 [1]。 该研究发现，IGFL1参与调控Basal-like（基底型）乳腺癌细胞的增殖和肿瘤的生长，并进一步鉴定IGFL1是一种促癌基因，这将为乳腺癌靶向治疗提供新的思路。 作为一款小众靶点，IGFL1目前处于非常早期的研究阶段。

May 27, 2011 · Finally, using a secreted and transmembrane protein library, we discovered high affinity interactions between human IGFL1 and mIGFL and the TMEM149 ectodomain. TMEM149 (renamed here as IGFLR1) is an uncharacterized gene with structural similarity to the tumor necrosis factor receptor family.

May 27, 2011 · In vitro, IGFL1 is produced by keratinocytes, and TNFα enhances its expression. Finally, we found that both mIGFL and IGFL1 interact with specificity and high affinity to a novel receptor (formerly TMEM149, now renamed as IGFLR1 for “IGF-like family receptor 1”) that bears similarity to the tumor necrosis factor receptor (TNFR) family.

Jan 4, 2025 · Title: Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. The -1245 A-allele of the IGF1 promoter single nucleotide polymorphism is associated with a small head size and less brain sparing in small for gestational ...

IGFL1 is a prognostic marker in Lung squamous cell carcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.

Oct 1, 2006 · The IGF-like (IGFL) genes encode proteins of approximately 100 amino acids that contain 11 conserved cysteine residues at fixed positions, including two CC motifs. In H. sapiens, the family is composed of four genes and two pseudogenes that are referred as IGFL1 to IGFL4 and IGFL1P1 and IGFL1P2, respectively. Human IGFL genes are clustered ...

该基因编码的蛋白质是胰岛素样生长因子信号分子家族的成员。 编码的蛋白质被合成为前体蛋白质，并被蛋白水解切割以形成分泌的成熟肽。 成熟的肽与受体结合，在小鼠中发现该受体存在于 T 细胞的细胞表面。 该基因表达增加可能与牛皮癣有关。 [RefSeq 提供，2016 年 8 月] The protein encoded by this gene is a member of the insulin-like growth factor family of signaling molecules.

体外 igfl1 表达在培养的原代角质形成细胞中被肿瘤坏死因子 α 上调，但不被其他银屑病相关细胞因子刺激。 最后，使用分泌的跨膜蛋白文库，我们发现了人 IGFL1 和 mIGFL 与 TMEM149 胞外域之间的高亲和力相互作用。

This study aimed to determine the potential role of insulin growth factor-like family member 1 (IGFL1) in lung adenocarcinoma (LUAD). We analyzed the expression of IGFL1 using TIMER, UALCAN, and GEPIA. The association of IGFL1 expression with symptoms and overall survival (OS) in LUAD patients was evaluated using a tissue microarray (TMA).