
Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): …
2020年5月5日 · Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an …
Mayo Clinic Laboratories | Endocrinology Catalog
Insulin-like growth factor-binding protein 3 (IGFBP-3) is a 264-amino acid peptide (molecular weight 29 kDa) produced by the liver. It is the most abundant of a group of IGFBPs that …
IGFBP-1 in cancer: expression, molecular mechanisms, and …
In this review, we provided an overview of IGFBP-1 in normal physiology, and its aberrantly expression and the underlying molecular mechanisms in a range of common tumors, as well …
IGF-Binding Proteins: Why Do They Exist and Why Are There So …
2018年4月8日 · In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF-binding protein (IGFBP) family, of which six distinct types exist. These …
Insulin-like growth factors: Ligands, binding proteins, and …
The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical …
Regulation of IGFBP-1 in Metabolic Diseases - PMC
IGFBP-1 secretion is regulated by a variety of pathological and physiological signals . Serum level of IGFBP-1 is associated with metabolic nutritional factors and increases IGF-1 concentration, …
IGF binding proteins in cancer: mechanistic and clinical insights
2014年4月10日 · The insulin-like growth factor (IGF) binding proteins (IGFBPs) are a family of six proteins that function as transport proteins for IGF-I and IGF-II in the circulation and also...
IGFB3 - Overview: Insulin-Like Growth Factor-Binding Protein 3, …
For all applications, insulin-like growth factor 1 (IGF-1) measurement has generally been shown to have superior diagnostic sensitivity and specificity compared with insulin-like growth factor …
The insulin-like growth factor-binding protein (IGFBP) superfamily
Over the last decade, the concept of an IGFBP family has been well accepted, based on structural similarities and on functional abilities to bind IGFs with high affinities. The existence of other …
Insulin-Like Growth Factor Binding Protein-5 in Physiology and …
2020年3月3日 · Insulin-like growth factor (IGF) signaling is regulated by a conserved family of IGF binding proteins (IGFBPs) in vertebrates. Among the six distinct types of IGFBPs, IGFBP-5 is …
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