IGF-1 plays an important role in growth and continues to have anabolic effects in adults – meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice …

2024年12月25日 · IGF1R (Insulin Like Growth Factor 1 Receptor) is a Protein Coding gene. Diseases associated with IGF1R include Insulin-Like Growth Factor I and Growth Delay Due …

2019年10月8日 · Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation, and can be activated by IGF1, IGF2, and insulin. …

IGF1R is an entry receptor for respiratory syncytial virus. Decoding molecular interplay between RUNX1 and FOXO3a underlying the pulsatile IGF1R expression during acquirement of …

The growth-promoting effects of IGF-I is mediated through the IGF-I receptor (IGFIR), a widely expressed, cell-surface tyrosine kinase receptor. IGF1R copy number variants (CNV) can …

Signalling through the IGF-1R is the principal pathway responsible for somatic growth in fetal mammals, while somatic growth in postnatal animals is achieved through the synergistic …

2003年11月6日 · Activation of the IGF-1R triggers several signaling pathways. The IGF-1R is a tyrosine kinase that undergoes autophosphorylation and catalyzes the phosphorylation of …

We show that IR preferentially stimulates phosphorylations associated with mammalian target of rapamycin complex 1 (mTORC1) and Akt pathways, whereas IGF1R preferentially stimulates …

2022年7月15日 · Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported …

The IGF1 receptor (IGF1R) has been shown to be expressed in a wide range of tumors, and IGF1R signaling is crucial for tumor transformation and the survival of malignant cells.