Immunoglobulin G (IgG) is one of the most abundant proteins in human serum, accounting for about 10–20% of plasma protein. It is the major class of the five classes of immunoglobulins in human beings, IgM, IgD, IgG, IgA, and IgE.

An Immunoglobulin G2a Antibody is a type of monoclonal antibody that exhibits cytotoxicity against tumor cells by inhibiting DNA synthesis and proliferation, as demonstrated in the context of cancer therapy studies. You might find these chapters and articles relevant to this topic. Dimitry A. Chistiakov, ... Vladimir P. Chekhonin.

What is IgG2a? Immunoglobulin G (IgG) is the most abundant Ig isotype in serum, making up approximately 80% of all serum Immunoglobulins. In mice, the IgG subclasses are defined IgG1, IgG2a/c, IgG2b, and IgG3.

Immunoglobulin G2a (IgG2a) is a subtype of the IgG class of antibodies that is predominantly induced in viral and intracellular bacterial infections, playing a key role in the immune response against such pathogens.

Human IgG2 antibody displays distinct therapeutically-useful properties compared with the IgG1, IgG3, and IgG4 antibody subclasses. IgG2 is the second most abundant IgG subclass, being able to bind human FcγRII/FcγRIII but not to FcγRI or complement C1q.

2012年6月14日 · It follows that all activating mouse FcγRs (FcγRI, FcγRIII, and FcγRIV) bind to IgG2a and IgG2b, whereas FcγRIII is the only activating FcγR binding IgG1 and FcγRI the only activating FcγR binding IgG3.

IgG2a can efficiently activate the complement cascade and is a mediator of antibody-dependent cytotoxicity by binding to specific Fc receptors on macrophages. IgG1 is dominant in parasitic infections.

In the past, we performed a range of studies where we compared the targeting behaviour of several rat monoclonal IgG2a and IgG2b antibodies in a fully homologous experimental system in vivo.

In this work, we designed and engineered an alternate technology for efficiently producing native IgG1 and IgG2a mouse bispecific antibodies.

2004年5月1日 · In this study, we investigate how the production of IgG, an early step in the chain of events leading to inflammation, is regulated by activating and inhibitory FcγRs. IgG Abs are known to feedback-enhance Ab responses to soluble Ags, …