Ionized calcium binding adaptor molecule 1 (Iba1) is a microglia/macrophage-specific calcium-binding protein. Iba1 has the actin-bundling activity and participates in membrane ruffling and phagocytosis in activated microglia.

Jun 17, 2021 · IBA1 is a novel, highly sensitive, and specific marker for diagnosing neoplasms of monocytic/histiocytic and DC origin.

IBA1 (Ionized calcium-binding adaptor molecule 1), also called allograft inflammatory factor 1 (AIF 1), is a well-established marker for microglia/macrophages. It is a 17-kDa EF hand calcium binding protein and it is upregulated during the activation of microglia/macrophages.

Dec 24, 2024 · AIF1 (Allograft Inflammatory Factor 1) is a Protein Coding gene. Diseases associated with AIF1 include Nonarteritic Anterior Ischemic Optic Neuropathy and Traumatic Brain Injury. Among its related pathways are Acute viral myocarditis and Spinal cord injury.

5 days ago · IBA1 is a defining marker for myeloid-lineage cells, particularly microglia and macrophages, due to its exclusive expression in these populations. Unlike markers shared across multiple immune cell types, IBA1 effectively distinguishes myeloid cells …

Iba1 is a marker for microglial cells and previous immunocytochemical studies have utilized this and other microglial-specific antibodies to demonstrate the morphological features of microglial cells at the light microscopic level.

Iba1 (ionized calcium binding adapter protein 1) is a cytoskeleton protein specific only for microglia and macrophages, where it acts as an actin-cross linking protein.

Feb 4, 2021 · To investigate the changes of Iba-1 and other potential markers for microglia activation in experimental diabetic retinopathy (DR). Male Sprague-Dawley rats were rendered diabetes via intraperitoneal injection of streptozotocin. The retinas were harvested at 1 to 24wk after diabetes onset.

Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein linked to the activation of macrophages. AIF1 is a key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has …

Feb 14, 2021 · IBA1 is a novel, highly sensitive, and specific marker for diagnosing neoplasms of monocytic/histiocytic and DC origin.