
ISG15 - Wikipedia
Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. [5] [6] ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier.
ISG15 in antiviral immunity and beyond - Nature
2018年5月16日 · Ubiquitin-like protein ISG15 is an interferon-induced protein that has been implicated as a central player in the host antiviral response. Over the past 15 years, efforts to understand how...
ISG15 Gene - GeneCards | ISG15 Protein | ISG15 Antibody
2024年12月25日 · ISG15 (ISG15 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with ISG15 include Immunodeficiency 38 With Basal Ganglia Calcification and Influenza. Among its related pathways are SARS-CoV-2 Infection and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template.
ISG15: Its Roles in SARS-CoV-2 and Other Viral Infections
Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like pleiotropic protein and one of the most abundant ISGs, has been studied extensively; however, its roles in SARS-CoV-2 and other viral infections have just begun to be elucidated.
The diverse repertoire of ISG15: more intricate than initially thought
2022年11月1日 · ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like protein (UBL), which plays multifaceted roles not only as a free intracellular or...
ISG15 deficiency and increased viral resistance in humans but …
2016年5月19日 · ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule, intracellularly and extracellularly, and conjugated to target proteins. Studies in mice have...
ISG15, a Small Molecule with Huge Implications: Regulation of ...
Interferon-stimulated gene 15 (ISG15) plays an important antiviral role during viral infection. ISG15 catalyzes a ubiquitin-like post-translational modification termed ISGylation, involving the conjugation of ISG15 molecules to de novo synthesized viral or cellular proteins, which regulates their stability and function. Numerous biomedically ...
ISG15, an Interferon-Stimulated Ubiquitin-Like Protein, Is Not ...
ISG15 is an interferon-induced ubiquitin-like modifier which can be conjugated to distinct, but largely unknown, proteins. ISG15 has been implicated in a variety of biological activities, which encompass antiviral defense, immune responses, and pregnancy.
ISG15: A link between innate immune signaling, DNA replication, …
2023年5月5日 · Interferon stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is highly induced upon activation of interferon signaling and cytoplasmic DNA sensing pathways. As part of the innate immune system ISG15 acts to inhibit viral replication and particle release via the covalent conjugation to both viral and host proteins.
ISG15 and ISGylation in Human Diseases - PubMed
2022年2月4日 · ISG15 and ISGylation have both inhibitory and/or stimulatory roles in the etiology and pathogenesis of human diseases. Thus, ISG15 is considered a "double-edged sword" for human diseases in which its expression is elevated.