
ISG15 - Wikipedia
Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. [5] [6] ISG15 is induced by type I interferon (IFN) and serves many functions, …
ISG15 in antiviral immunity and beyond - Nature
2018年5月16日 · Ubiquitin-like protein ISG15 is an interferon-induced protein that has been implicated as a central player in the host antiviral response. Over the past 15 years, efforts to …
ISG15 Gene - GeneCards | ISG15 Protein | ISG15 Antibody
2024年12月25日 · ISG15 (ISG15 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with ISG15 include Immunodeficiency 38 With Basal Ganglia Calcification and …
ISG15: Its Roles in SARS-CoV-2 and Other Viral Infections
Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like pleiotropic protein and one of the most abundant ISGs, has been studied extensively; however, its roles in SARS-CoV-2 and …
The diverse repertoire of ISG15: more intricate than initially thought
2022年11月1日 · ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like protein (UBL), which plays multifaceted roles not only as a free intracellular or...
ISG15 deficiency and increased viral resistance in humans but …
2016年5月19日 · ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule, intracellularly and extracellularly, and conjugated to target proteins. Studies in mice …
ISG15, a Small Molecule with Huge Implications: Regulation of ...
Interferon-stimulated gene 15 (ISG15) plays an important antiviral role during viral infection. ISG15 catalyzes a ubiquitin-like post-translational modification termed ISGylation, involving the …
ISG15, an Interferon-Stimulated Ubiquitin-Like Protein, Is Not ...
ISG15 is an interferon-induced ubiquitin-like modifier which can be conjugated to distinct, but largely unknown, proteins. ISG15 has been implicated in a variety of biological activities, which …
ISG15: A link between innate immune signaling, DNA replication, …
2023年5月5日 · Interferon stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is highly induced upon activation of interferon signaling and cytoplasmic DNA sensing pathways. …
ISG15 and ISGylation in Human Diseases - PubMed
2022年2月4日 · ISG15 and ISGylation have both inhibitory and/or stimulatory roles in the etiology and pathogenesis of human diseases. Thus, ISG15 is considered a "double-edged sword" for …