
Advances and challenges in targeting IRF5, a key regulator of ...
Interferon regulatory factor 5 (IRF5) belongs to a family of transcription factors, originally implicated in antiviral responses and interferon production. However, studies conducted in …
Advances and challenges in targeting IRF5, a key regulator of ...
Here, we review the advances made by various studies in targeting multiple steps of signalling leading to IRF5 activation with their therapeutic potential, and the possible complications of …
IRF5 Gene - GeneCards | IRF5 Protein | IRF5 Antibody
2024年12月25日 · IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Inflammatory Bowel Disease 14 and Systemic Lupus …
IRF5 Is a Specific Marker of Inflammatory Macrophages In Vivo
Previously, our laboratory identified the transcription factor interferon regulatory factor 5 (IRF5) as the master regulator of the M1 macrophage polarisation. IRF5 was found to be highly …
IRF5 gene - MedlinePlus
The protein produced from the IRF5 gene, called interferon regulatory factor 5 (IRF5), acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps …
Activation and function of interferon regulatory factor 5
We discuss suggested models of IRF5 activation in connection to pathway-specific functions of IRF5. Interferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of …
Phosphorylation of Microglial IRF5 and IRF4 by IRAK4 Regulates ...
Background: Interferon Regulatory Factor (IRF) 5 and 4 play a determinant role in regulating microglial pro- and anti-inflammatory responses to cerebral ischemia. How microglial IRF5 and …
IRF5 interferon regulatory factor 5 [ Homo sapiens (human) ]
2025年3月4日 · Title: IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation. M6A-induced transcription factor …
Role of interferon regulatory factor 5 (IRF5) in tumor progression ...
Canonically, the transcription factor interferon regulatory factor 5 (IRF5) is a key mediator of innate and adaptive immunity downstream of pathogen recognition receptors such as Toll-like …
Role of interferon regulatory factor 5 (IRF5) in tumor progression ...
2024年1月1日 · Interferon Regulatory Factor 5 (IRF5) is among nine mammalian members of the interferon regulatory factor (IRF) family of transcription factors that mediate interferon (IFN) …
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