Interferon regulatory factor 5 (IRF5) belongs to a family of transcription factors, originally implicated in antiviral responses and interferon production. However, studies conducted in …

Here, we review the advances made by various studies in targeting multiple steps of signalling leading to IRF5 activation with their therapeutic potential, and the possible complications of …

2024年12月25日 · IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Inflammatory Bowel Disease 14 and Systemic Lupus …

Previously, our laboratory identified the transcription factor interferon regulatory factor 5 (IRF5) as the master regulator of the M1 macrophage polarisation. IRF5 was found to be highly …

The protein produced from the IRF5 gene, called interferon regulatory factor 5 (IRF5), acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps …

We discuss suggested models of IRF5 activation in connection to pathway-specific functions of IRF5. Interferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of …

Background: Interferon Regulatory Factor (IRF) 5 and 4 play a determinant role in regulating microglial pro- and anti-inflammatory responses to cerebral ischemia. How microglial IRF5 and …

2025年3月4日 · Title: IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation. M6A-induced transcription factor …

Canonically, the transcription factor interferon regulatory factor 5 (IRF5) is a key mediator of innate and adaptive immunity downstream of pathogen recognition receptors such as Toll-like …

2024年1月1日 · Interferon Regulatory Factor 5 (IRF5) is among nine mammalian members of the interferon regulatory factor (IRF) family of transcription factors that mediate interferon (IFN) …