2006年9月1日 · In the MyD88-dependent pathway, IRF4, IRF5 and IRF7 directly interact with MyD88 and regulate gene-expression programmes in this way. IRF7 is essential for the robust type I IFN gene induction...

IRF4 is an essential regulatory component at various stages of B cell development. In early B cell development, IRF4 functions alongside IRF8 to induce the expression of the Ikaros and Aiolos transcription factors, which decrease expression of the pre-B-cell-receptor. [9] .

2024年10月9日 · In mammals, nine IRF members have been reported, 10 designated as IRF1 (also known as MAR), IRF2, IRF3, IRF4 (known alternatively as LSIRF/ICSAT/ PIP), IRF5, IRF6, IRF7, IRF8 (also termed as...

In this section, we describe our studies that have led us to uncover an unexpected link between IRF4 and Rho GTPase-mediated pathways as one of the key mechanisms that restrains the function of IRF4 under neutral conditions.

2019年11月26日 · IRF4 regulates genes involved in numerous cellular processes, with RNA changes upon deletion seen in several pathways but with a particular predilection for cell surface receptors and intracellular signaling pathways (Figure 2C).

2024年12月25日 · IRF4 (Interferon Regulatory Factor 4) is a Protein Coding gene. Diseases associated with IRF4 include Skin/Hair/Eye Pigmentation, Variation In, 8 and Whipple Disease. Among its related pathways are MITF-M-dependent gene expression and Signaling by ALK fusions and activated point mutants.

2016年11月7日 · In this study, we provide evidence that Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) promotes IRF4 phosphorylation and markedly stimulates IRF4 transcriptional activity, and that...

2015年2月1日 · TLRs initiate shared and distinct signaling pathways by recruiting different combinations of four TIR domain-containing adaptor molecules: MyD88, TIRAP (MAL), TRIF (TICAM1), and TRAM [29].

2016年10月18日 · Our data show that IRF4 expression in M2 macrophages is dependent on both IL-4-Stat6 and M-CSF-mTORC2, and this is compatible with the fact that in T cells, IRF4 also integrates disparate extracellular signals from cytokine receptors, T cell receptors, and nutrient sensing pathways to sustain metabolic remodeling and appropriate cellular function.

Objective: To investigate the effect of macrophage polarization mediated by Jumonji domain containing-3 (JMJD3)-interferon regulatory factor 4 (IRF4) signaling pathway on the malignant biological behavior of multiple myeloma (MM) cells. Methods: THP-1 monocytes were induced to differentiate into macrophages by phorbol myristate acetate (PMA).