Interleukin-1 receptor-associated kinase 1 (IRAK-1) is an enzyme in humans encoded by the IRAK1 gene. [5] [6] IRAK-1 plays an important role in the regulation of the expression of inflammatory genes by immune cells, such as monocytes and macrophages, which in turn help the immune system in eliminating bacteria, viruses, and other pathogens.

一类与IL-1R和TLR信号转导相关的丝氨酸-苏氨酸蛋白激酶，已发现IRAK-1、IRAK-2、IRAK-M和IRAK-4，均含死亡结构域 (DD)。 IRAK1、IRAK2表达广泛，IRAK-M仅表达于单核细胞来源的细胞。 磷酸化IRAK-1可与TRAF6结合，激活NF-κB。 一类与IL-1R和TLR信号转导相关的丝氨酸-苏氨酸蛋白激酶，已发现IRAK-1、IRAK-2、IRAK-M和IRAK-4，均含死亡结构域 (DD)。 IRAK1、IRAK2表达广泛，IRAK-M仅表达于单核细胞来源的细胞。 磷酸化IRAK-1可与TRAF6结合，激 …

Interleukin-1 receptor activated kinases (IRAKs) are key mediators in the signaling pathways of TLRs/IL-1Rs. By means of their kinase and adaptor functions, IRAKs initiate a cascade of signaling events eventually leading to induction of inflammatory target gene expression.

2024年12月25日 · IRAK1 (Interleukin 1 Receptor Associated Kinase 1) is a Protein Coding gene. Diseases associated with IRAK1 include Pediatric Systemic Lupus Erythematosus and Mumps. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Bacterial infections in …

IRAK1 is a threonine/serine kinase. Unlike IRAK4, IRAK1 is not a core constituent of the Myddosome but transiently interacts with IRAK4 upon Myddosome assembly. Unlike IRAK4, IRAK1 exists primarily in an inactive conformation at the basal state and requires upstream stimulation for rapid activation .

Interleukin receptor-associated kinase (IRAK) proteins are pivotal in interleukin-1 and Toll-like receptor-mediated signaling pathways. They play essential roles in innate immunity and inflammation. This review analyzes and discusses the physiological functions of IRAK1 and its associated diseases.

2024年5月9日 · Interleukin receptor-associated kinase (IRAK) proteins are pivotal in interleukin-1 and Toll-like receptor-mediated signaling pathways. They play essential roles in innate immunity and inflammation. This review analyzes and discusses the physiological functions of IRAK1 and its associated diseases.

2014年10月7日 · Interleukin-1 receptor-associated kinase (IRAK) family members are mediators of TLR/IL1R superfamily signalling, and mounting evidence implicates these kinases as viable cancer...

2008年2月1日 · Interleukin-1 receptor activated kinases (IRAKs) are key mediators in the signaling pathways of TLRs/IL-1Rs. By means of their kinase and adaptor functions, IRAKs initiate a cascade of signaling events eventually leading to …

IRAK1 Is a Critical Mediator of Inflammation-Induced Preterm Birth. A new insight into thymosin beta4, a promising therapeutic approach for neurodegenerative disorders. Polymorphisms of IRAK1 Gene on X Chromosome Is Associated with Hashimoto Thyroiditis in Korean Children.