The IP3R [IP3 (inositol 1,4,5-trisphosphate) receptor] is responsible for Ca2+ release from the ER (endoplasmic reticulum). We have been working extensively on the P400 protein, which is deficient in Purkinje-neuron-degenerating mutant mice.

Three IP 3 R isoforms are responsible for the generation of intracellular Ca 2+ signals that may spread across the entire cell or occur locally in so-called microdomains. Because of their ubiquitous expression, these channels are involved in the regulation of a plethora of cellular processes, including cell survival and cell death.

In both nonexcitable and excitable cells, the inositol 1,4,5-trisphosphate receptor (IP3R) is the primary cytosolic target responsible for the initiation of intracellular calcium (Ca2+) signaling. ...

Type 3 inositol 1,4,5-triphosphate receptor (IP3R3) is an a tetrameric channel that can mediate the release of Ca 2+ from the endoplasmic reticulum (ER) in response to extracellular stimuli. The gating of IP3R3 is regulated not only by ligands but also by other interacting proteins.

Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) are ubiquitously expressed large-conductance Ca 2+ -permeable channels predominantly localized to the endoplasmic reticulum (ER) membranes of virtually all eukaryotic cell types.

Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular calcium (Ca 2+) release channels located on the sarco/endoplasmic reticulum (SR/ER), the major Ca 2+ store in the cells.

2019年8月19日 · Using an IP3R-deficient cell model rescued with each of the three IP3R isoforms and an array of super-resolution and ultrastructural approaches we demonstrate that IP3Rs are required for...

2022年3月17日 · A pivotal component of the calcium (Ca2+) signaling toolbox in cells is the inositol 1,4,5-triphosphate (IP3) receptor (IP3R), which mediates Ca2+ release from the endoplasmic reticulum (ER ...

The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) type 2 (IP3R2) is an intracellular Ca²⁺-release channel located on the endoplasmic reticulum (ER). IP3R2 is characterized by a high sensitivity to both IP3 and ATP and is biphasically regulated by Ca²⁺.

2021年2月10日 · Intracellular ion channel inositol 1,4,5-triphosphate receptor (IP3R1) releases Ca 2+ from endoplasmic reticulum. The disturbance of IP3R1 is related to several neurodegenerative...