ILC2s play the crucial role of secreting type 2 cytokines in response to large extracellular parasites. They express characteristic surface markers and receptors for chemokines, which are involved in distribution of lymphoid cells to specific organ sites.

Group 2 innate lymphoid cells (ILC2s) play critical roles in the induction of type 2 inflammation, response to parasite infection, metabolic homeostasis, and tissue repair.

Apr 13, 2022 · ILC2 provide an innate source of type-2 cytokines (IL-5, IL-9 and IL-13). IL-13 production by ILC2 is critical to anti-helminthic immunity. ILC2 regulate allergic airways inflammation and lung tissue homeostasis. ILC2 development is instructed by the transcriptional regulators, RORα and Gata3. Bone marrow ILC2 precursors give rise to mature ...

Group 2 innate lymphoid cells (ILC2) have emerged as a major component of type 2 inflammation in mice and humans. ILC2 secrete large amounts of interleukins 5 and 13, which are largely responsible for host protective immunity against helminth ...

Mar 30, 2022 · More than a decade ago, type 2 innate lymphoid cells (ILC2s) were discovered to be members of a family of innate immune cells consisting of five subsets that form a first line of defence...

Jan 10, 2024 · Group 2 innate lymphoid cells (ILC2s) are characterized by expression of GATA3 and the production of Th2 cell-associated cytokines, including IL-4, IL-5, IL-9, and IL-13 as well as amphiregulin (AREG), in response to stimulation with the cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP). 8 In mice, two main subgroups of ILC2s have ...

Mar 20, 2023 · This review summarizes the interactions between ILC2s and surrounding cells, including epithelial cells, neurons, immune cells, and mesenchymal cells, with the objective of promoting the development of novel diagnostic and therapeutic methods for …

The dendritic cell [DC]-T helper 2 (Th2) cell axis is the conventional type 2 immune pathway, and is currently known as the group 2 innate lymphoid cell (ILC2)-DC-Th2 axis that mediates type 2 inflammation.

Aug 7, 2024 · Here we show that disruption of leukaemia inhibitory factor (LIF) production from group 2 innate lymphoid cells (ILC2s) prevents immune cells leaving the lungs to migrate to the lymph nodes...

May 8, 2019 · Group 2 innate lymphoid cells (ILC2) have emerged as a major component of type 2 inflammation in mice and humans. ILC2 secrete large amounts of interleukins 5 and 13, which are largely responsible for host protective immunity against helminth parasites because these cytokines induce profound changes …