The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta and the common gamma chain .

2024年12月25日 · IL2RA (Interleukin 2 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL2RA include Immunodeficiency 41 With Lymphoproliferation And Autoimmunity and Type 1 Diabetes Mellitus 10. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and TGF-Beta Pathway.

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a …

Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway plays a pivotal role within these processes. The most striking functions of the IL-2 – IL-2R pathway are the differential induction of autoimmune responses and tolerance.

The IL2RA gene is composed of eight exons and encodes the α chain of the IL-2 receptor complex (also known as CD25). IL2RA is central to immune regulation as an important modulator of immunity. IL2RA expression on regulatory T cells is essential for their function in suppressing T cell immune responses and autoimmune disease [58–60] .

2018年8月8日 · This study identifies a STAT5-based super-enhancer as the key regulatory element mediating IL-2-induced gene regulation of Il2ra and dissects the functional elements of the super-enhancer.

PD1-IL2Ra-IL2 demonstrated PD-1-targeting-dependent IL-2 activity in vitro and promoted the expansion of tumor-infiltrating PD-1 + CD8 T cells with highly functional effector profiles in vivo. Treatment with PD1-IL2Ra-IL2 results in robust tumor growth inhibition and enhanced survival in …