It is encoded in human by the IL23R gene. [5] In complex with the interleukin-12 receptor β1 subunit , it is activated by the cytokine interleukin 23 (IL-23). [6] The IL23R mRNA is 2.8 kilobases in length and includes 12 exons.

2024年12月25日 · IL23R (Interleukin 23 Receptor) is a Protein Coding gene. Diseases associated with IL23R include Inflammatory Bowel Disease 17 and Psoriasis 7. Among its related pathways are Akt Signaling and Cytokine production by Th17 cells in CF (Mouse model).

The IL23R gene provides instructions for making a protein called the interleukin 23 (IL-23) receptor. This protein is embedded in the outer membrane of several types of immune system cells, including T cells, natural killer (NK) cells, monocytes, and dendritic cells.

Interleukin-23 (IL-23) is a member of the IL-12 family of cytokines with pro-inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 (Th17) cells indicates the responsibility for many of the inflammatory autoimmune responses.

Here, we focus on two questions: what are the immune cells that express the IL23R and how is IL23R expression acquired. The IL-23R: Structure and signaling IL-23 is a heterodimeric cytokine formed by two disulfide-bound subunits: p19 (encoded by IL23A ) …

Here we review current understanding of IL-23 biology and explore its pleiotropic effects on T cells, and innate lymphoid, myeloid and intestinal epithelial cells in the context of the pathogenesis of IBD.

2024年12月10日 · In plasma from humans across the lifespan, IL-23R increased with age. Our results reveal circulating factors as candidate mediators of senescence-associated interorgan signal transduction and...

2023年5月19日 · In this study, we use a fluorescent version of IL-23 to characterise antagonists of the full-length receptor expressed by living cells using a NanoBRET competition assay. We then develop a cyclic...

2025年2月8日 · IL23R gene is one of the genetic factors implicated in the genetics of IBD in the general population. We conclude that the IL23R gene does not seem to be associated with rheumatoid arthritis predisposition in a Spanish population. IL23R is …

IL23R was critical for optimal levels of pattern-recognition receptor (PRR)-induced signalling and cytokines in human MDMs.