2024年12月25日 · IL12B (Interleukin 12B) is a Protein Coding gene. Diseases associated with IL12B include Immunodeficiency 29 and Immunodeficiency 27A. Among its related pathways …

Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is …

2025年2月8日 · Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This …

IL-12 is composed of p35 (encoded by Il12a) and p40 (encoded by Il12b) chains, and it principally activates natural killer (NK) cells and induces the differentiation of naïve CD4 + T lymphocytes …

2020年12月11日 · In this review, we will provide an update on functional activities of IL-12 and their implications for disease. We will begin with a summary on structure and function of the …

One of the cancer-risk loci frequently identified was the SNP rs3212227 in IL12B, which shows significant association to overall cancer risk, especially among Asians, and, particularly, to …

Interleukin-12 (IL12) is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-γ production by natural-killer and T lymphocytes. It consists of two …

2024年3月5日 · Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This …

Interleukin-12 (IL12) is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-gamma production by natural-killer and T lymphocytes. It consists of …

Disease-causing germline mutation(s) in Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency ORPHA:319558