Interleukin 6 receptor (IL6R) also known as CD126 (C luster of D ifferentiation 126) is a type I cytokine receptor. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.

2024年12月25日 · IL6R (Interleukin 6 Receptor) is a Protein Coding gene. Diseases associated with IL6R include Hyper-Ige Syndrome 5, Autosomal Recessive, With Recurrent Infections and Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus. Among its related pathways are TGF-Beta Pathway and MIF Mediated Glucocorticoid Regulation.

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.

2019年5月17日 · Soluble IL-6Rα (sIL-6Rα) is an agonist of IL-6-induced signalling and allows cells that do not express transmembrane IL-6Rα to respond to IL-6. Signalling via membrane-bound IL-6Rα is denoted as classic signalling, while signalling via soluble IL-6Rα is denoted as trans-signalling.

2020年2月15日 · In this study, we developed a mouse model, in which murine IL-6 is overexpressed in a CD11c-Cre–dependent manner. Transgenic mice developed a lethal immune dysregulation syndrome with increased numbers of Ly-6G + neutrophils and Ly-6C hi monocytes/macrophages.

Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and the signaling molecule, gp130.

2018年1月1日 · The interleukin-6 receptor (IL-6R) is a type I transmembrane protein that was cloned and described in 1988 (Yamasaki et al. 1988). It serves as the non-signaling alpha-receptor of the multifunctional cytokine IL-6 and is expressed in a cell-type-specific manner.

2024年1月16日 · IL-6 engages with three distinct signaling pathways to regulate its biological effects: classical signaling, trans-signaling, and cluster signaling. Ultimately inducing anti-inflammatory effects, classical IL-6 signaling occurs when complex IL-6/mIL-6R/gp130 appears on the surface of selected cells. By contrast, trans-signaling results in pro ...

Since its discovery nearly 50 years ago, the IL-6 signaling pathway has emerged as a key pathway involved in immune regulation in health and immune dysregulation in many diseases. In the classical pathway, IL-6 binds to both transmembrane and soluble forms of its receptor IL-6 R，namely mIL-6R and sIL-6R.

In this study, by using a conditional knockout (cKO) model with selective IL-6 receptor deletion in T cells (IL-6R–cKO), we demonstrated that T cell–specific IL-6R signaling is essential for viral control during persistent lymphocytic choriomeningitis virus clone 13 infection.