Insulin-like growth factor 2 receptor (IGF2R), also called the cation-independent mannose-6-phosphate receptor (CI-MPR) is a protein that in humans is encoded by the IGF2R gene.

2024年12月25日 · IGF2R (Insulin Like Growth Factor 2 Receptor) is a Protein Coding gene. Diseases associated with IGF2R include Hepatocellular Carcinoma and Pompe Disease. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Innate Immune System.

Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like and mitogenic activities.

IGF2R is a multifunctional receptor that possesses binding sites for diverse ligands, including insulin-like growth factor II (IGF2; 147470), retinoic acid, TGF-beta (TGFB1; 190180), urokinase-type plasminogen activator receptor (UPAR, or PLAUR; 173391), and mannose-6-phosphate (M6P), a modification characteristic of lysosomal enzymes.

IGF2R is a prognostic marker in Cervical squamous cell carcinoma and endocervical adenocarcinoma, Kidney renal clear cell carcinoma

2013年3月12日 · Both IGF1 and IGF2 signal through the IGF1R leading to the growth and metabolic effects via the downstream PI3K/Akt pathway. IGF2R is not a signaling receptor but is instead involved in the capture and degradation of extracellular IGF2 …

Insulin-like growth factor II (IGF-II) receptor, also widely known as cation-independent mannose 6-phosphate receptor (CI-M6PR), is a multifunctional type I transmembrane glycoprotein that participates in the internalization of mannose-6-phosphate modified hydrolases and IGF-II from the plasma membrane (1,2).

1998年11月1日 · Insulin-like growth factor II (IGF-II) and phosphomannosylated glycoproteins bind to distinct sites on the same receptor, the IGF-II/mannose 6-phosphate receptor (IGF2R).

2011年1月11日 · Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends. Belongs to the MRL1/IGF2R family. Search… The displayed sequence is further processed into a mature form.

2004年3月1日 · Preferential transcription of maternally-derived allele in some mammals with the exception of primates and close relatives. Humans harbor a parentally imprinted differentially methylated CpG island, but human IGF2R transcripts are not preferentially maternally derived.