
IGF2BP2 Gene - GeneCards | IF2B2 Protein | IF2B2 Antibody
2024年12月25日 · IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) is a Protein Coding gene. Diseases associated with IGF2BP2 include Type 2 Diabetes Mellitus and Testicular Cancer. Among its related pathways are MAPK-Erk Pathway and Processing of Capped Intron-Containing Pre-mRNA.
IGF2BP2 - Wikipedia
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.
The role of IGF2BP2, an m6A reader gene, in human metabolic …
Emerging evidence shows that IGF2BP2 is an N6-methyladenosine (m6A) reader that participates in the development and progression of cancers by communicating with different RNAs such as microRNAs (miRNAs), messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs). Additionally, IGF2BP2 is an independent prognostic factor for multiple cancer types.
IGF2BP2 insulin like growth factor 2 mRNA binding protein 2
2025年2月9日 · Gene ID: 10644, updated on 9-Feb-2025. This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene …
The m6A reader IGF2BP2 regulates glycolytic metabolism and …
2024年3月5日 · Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) is a newly identified m 6 A-binding protein that functions to enhance mRNA stability and translation. However,...
IGF2BP2 promotes cancer progression by degrading the RNA ... - PNAS
IGF2BP2 has been suggested to have important roles in a wide range of biological and disease processes including embryonic development, neurogenesis, metabolism, insulin resistance, and cancer progression . There have been a number of lines of evidence implicating IGF2BP2 as a tumor promoter.
RNA binding protein IGF2BP2 expression is induced by stress in …
2023年12月5日 · Enhanced expression of an IGF2BP2 transgene in a conditional, inducible mouse line leads to dilated cardiomyopathy (DCM) and death within 3-4 weeks in newborn or adult hearts. Downregulation of...
IGF2BP2 insulin like growth factor 2 mRNA binding protein 2 …
2025年2月9日 · IGF2BP2 Polymorphisms Are Associated with Clinical Characteristics and Development of Oral Cancer. Chou CH, et al. Int J Mol Sci, 2020 Aug 7. PMID 32784624, Free PMC Article. What's a GeneRIF? METTL3-mediated TIM1 promotes macrophage M1 polarization and inflammation through IGF2BP2-dependent manner.
IGF2BP family of RNA-binding proteins regulate innate and …
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP1, IGF2BP2, and IGF2BP3) are a family of RNA-binding proteins that play an essential role in the development and disease by regulating mRNA stability and translation of critical regulators of cell division and metabolism.
Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2
2025年2月8日 · IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. p62/IGF2BP2-2 drives the progression of NAFLD through elevation of hepatic iron deposition and increased production of hepatic free cholesterol.
The role of IGF2BP2, an m6A reader gene, in human metabolic
2021年2月10日 · Emerging evidence shows that IGF2BP2 is an N6-methyladenosine (m6A) reader that participates in the development and progression of cancers by communicating with different RNAs such as microRNAs (miRNAs), messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs).
The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 …
The insulin-like growth factor (IGF) 2 mRNA-binding protein (IGF2BP, IMP) family comprises three RBPs, IGF2BP1, IGF2BP2, and IGF2BP3, capable of associating with IGF2 and other transcripts and mediating their processing.
The Emerging Role of IGF2BP2 in Cancer Therapy Resistance: …
2024年11月12日 · IGF2BP2, as a reader of m6A methylation, plays a pivotal role in the post-transcriptional regulation of RNA through the methylation of m6A sites. It not only contributes to cancer initiation and progression but also plays a key role in tumor drug resistance.
The role of IGF2BP2, an m6A reader gene, in human metabolic …
2021年2月10日 · The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 was thought to be a type 2 diabetes (T2D)-associated gene.
IGF2BP2, an RNA-binding protein regulates cell proliferation and ...
In summary, IGF2BP2 is a potential biomarker and therapeutic target for osteoporosis and OGD. Keywords: IGF2BP2; RNA-binding protein; cell proliferation; osteogenic differentiation; serum response factor.
Two Isoforms of the mRNA Binding Protein IGF2BP2 Are …
2012年3月12日 · By immunoblotting with C-terminally reactive antibodies we identified a novel IGF2BP2 isoform with a molecular weight of 58 kDa in both human and rodents, that is expressed at somewhat lower levels than the full-length 65 kDa protein.
IGF2BP family of RNA-binding proteins regulate innate and …
2023年7月12日 · Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP1, IGF2BP2, and IGF2BP3) are a family of RNA-binding proteins that play an essential role in the development and disease by regulating mRNA stability and translation …
Insulin-like Growth Factor 2 mRNA-binding protein 2 (IGF2BP2
2024年4月10日 · Here, we investigate the role of IGF2BP2 in regulating AR-V7 expression and CRPC progression. We demonstrate that IGF2BP2 silencing leads to downregulation of AR-V7 and its downstream target genes without affecting AR levels.
The Emerging Role of IGF2BP2 in Cancer Therapy Resistance: …
IGF2BP2, as a reader of m6A methylation, plays a pivotal role in the post-transcriptional regulation of RNA through the methylation of m6A sites. It not only contributes to cancer initiation and progression but also plays a key role in tumor drug resistance.
IGF2BP1 - Wikipedia
Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene. [5] [6] [7]This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs.It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) …