2024年12月25日 · IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) is a Protein Coding gene. Diseases associated with IGF2BP2 include Type 2 Diabetes Mellitus and Testicular Cancer. Among its related pathways are MAPK-Erk Pathway and Processing of Capped Intron-Containing Pre-mRNA.

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.

Emerging evidence shows that IGF2BP2 is an N6-methyladenosine (m6A) reader that participates in the development and progression of cancers by communicating with different RNAs such as microRNAs (miRNAs), messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs). Additionally, IGF2BP2 is an independent prognostic factor for multiple cancer types.

2025年2月9日 · Gene ID: 10644, updated on 9-Feb-2025. This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene …

2024年3月5日 · Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) is a newly identified m 6 A-binding protein that functions to enhance mRNA stability and translation. However,...

IGF2BP2 has been suggested to have important roles in a wide range of biological and disease processes including embryonic development, neurogenesis, metabolism, insulin resistance, and cancer progression . There have been a number of lines of evidence implicating IGF2BP2 as a tumor promoter.

2023年12月5日 · Enhanced expression of an IGF2BP2 transgene in a conditional, inducible mouse line leads to dilated cardiomyopathy (DCM) and death within 3-4 weeks in newborn or adult hearts. Downregulation of...

2025年2月9日 · IGF2BP2 Polymorphisms Are Associated with Clinical Characteristics and Development of Oral Cancer. Chou CH, et al. Int J Mol Sci, 2020 Aug 7. PMID 32784624, Free PMC Article. What's a GeneRIF? METTL3-mediated TIM1 promotes macrophage M1 polarization and inflammation through IGF2BP2-dependent manner.

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP1, IGF2BP2, and IGF2BP3) are a family of RNA-binding proteins that play an essential role in the development and disease by regulating mRNA stability and translation of critical regulators of cell division and metabolism.

2025年2月8日 · IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. p62/IGF2BP2-2 drives the progression of NAFLD through elevation of hepatic iron deposition and increased production of hepatic free cholesterol.

2021年2月10日 · Emerging evidence shows that IGF2BP2 is an N6-methyladenosine (m6A) reader that participates in the development and progression of cancers by communicating with different RNAs such as microRNAs (miRNAs), messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs).

The insulin-like growth factor (IGF) 2 mRNA-binding protein (IGF2BP, IMP) family comprises three RBPs, IGF2BP1, IGF2BP2, and IGF2BP3, capable of associating with IGF2 and other transcripts and mediating their processing.

2024年11月12日 · IGF2BP2, as a reader of m6A methylation, plays a pivotal role in the post-transcriptional regulation of RNA through the methylation of m6A sites. It not only contributes to cancer initiation and progression but also plays a key role in tumor drug resistance.

2021年2月10日 · The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 was thought to be a type 2 diabetes (T2D)-associated gene.

In summary, IGF2BP2 is a potential biomarker and therapeutic target for osteoporosis and OGD. Keywords: IGF2BP2; RNA-binding protein; cell proliferation; osteogenic differentiation; serum response factor.

2012年3月12日 · By immunoblotting with C-terminally reactive antibodies we identified a novel IGF2BP2 isoform with a molecular weight of 58 kDa in both human and rodents, that is expressed at somewhat lower levels than the full-length 65 kDa protein.

2023年7月12日 · Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP1, IGF2BP2, and IGF2BP3) are a family of RNA-binding proteins that play an essential role in the development and disease by regulating mRNA stability and translation …

2024年4月10日 · Here, we investigate the role of IGF2BP2 in regulating AR-V7 expression and CRPC progression. We demonstrate that IGF2BP2 silencing leads to downregulation of AR-V7 and its downstream target genes without affecting AR levels.

IGF2BP2, as a reader of m6A methylation, plays a pivotal role in the post-transcriptional regulation of RNA through the methylation of m6A sites. It not only contributes to cancer initiation and progression but also plays a key role in tumor drug resistance.

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene. [5] [6] [7]This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs.It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) …