2024年12月25日 · IFNAR1 (Interferon Alpha And Beta Receptor Subunit 1) is a Protein Coding gene. Diseases associated with IFNAR1 include Immunodeficiency 106 Viral Infections and Primary Immunodeficiency With Predisposition To Severe Viral Infection .

2021年11月23日 · Type I interferons bind to cell surface receptors composed of the subunits IFNAR1 and IFNAR2, the intracellular domains (ICDs) of which are associated with the kinases TYK2 and JAK1, respectively.

Detection of interferon alpha and beta receptor subunit 1 (IFNAR1) loss-of-function Glu386 * variant by tri-allelic genotyping. Association of IFNAR1 and IFNAR2 with COVID-19 severity. CK1alpha upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.

IFNAR1 is a 100 kDa ligand-binding subunit encoded by genes on human chromosome 21 and including a TYK2 binding site. IFNAR2c, a 125 kDa polypeptide encoded by a gene on human chromosome 21, also plays an important role in ligand binding and signal transduction, which is mediated by JAK1. There are three forms of the IFNAR2 chain.

2025年1月5日 · Title: CK1α upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.

2024年12月16日 · We report 11 human IFNAR1 alleles, the products of which impair but do not abolish responses to IFN-α and -ω without affecting responses to IFN-β.

2013年7月21日 · Here we demonstrate IFN-β can uniquely and specifically ligate to IFNAR1 in an IFNAR2-independent manner, and we provide the structural basis of the IFNAR1–IFN-β interaction.

2024年3月5日 · Correlation between IFNAR1 expression in peripheral blood T lymphocytes and inflammatory cytokines, tumor-infiltrating lymphocytes, and chemosensitivity in patients with colorectal cancer. A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in …

2023年9月25日 · As a ligand, the N-terminus of secreted LRPAP1 binds with the extracellular domain of IFNAR1 that triggers the receptor ubiquitination and degradation and promotes virus infection both in...

2021年1月19日 · IFNAR1 is S-palmitoylated on the PM proximal Cys 463 residue. IFNAR1 cytosolic tail interacts with TYK2 kinase FERM and SH2 domains through a minimal region that corresponds to 486–511 residues (thick blue line).