The type III interferon group is a group of anti-viral cytokines, that consists of four IFN-λ (lambda) molecules called IFN-λ1, IFN-λ2, IFN-λ3 (also known as IL29, IL28A and IL28B respectively), and IFN-λ4. [1] They were discovered in 2003. [2]

ii型ifn家族由单一基因产物 ifnγ 组成，主要由t细胞和自然杀伤（nk）细胞产生，能作用于表达ifnγ受体（ifnγr）的细胞类型。iii型ifn家族包括 ifnλ1 、 ifnλ2 和 ifnλ3 （也分别称为il-29、il-28a和il-28b）以及ifnλ4。

2015年7月21日 · Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them...

在人类细胞中，i 型 ifn 包括 ifn-α 的 13 个亚型、ifn-β以及 ifn-ε 和 ifn-ω 组成。 III 型 IFN包括 IFN-λ1、IFN-λ2、IFN-λ3和 IFN-λ4，前三种与白细胞介素 10 （IL-10） 在结构上相关，IFN-λ4与 HCV 感染清除受损有关。

i、ii、iii型. i型ifn能与特定细胞表面受体ifn-α/β （ifnar1，ifnar2）结合，是未感染细胞的预警系统。在人体中，i型ifn是最大的ifn家族，包括ifn-α、ifn-β、 ifn-ε、ifn-κ和ifn-ω；它们由多种类型的细胞分泌，包括浆细胞样树突状细胞和成纤维细胞。

Interferon Type III, also known as IFN-λ, is a family of interferons characterized by three elements: λ1, λ2, and λ3, which exhibit antiviral properties similar to type I interferons by inducing Jak/STAT pathways and upregulating antiviral proteins.

2020年7月1日 · IFN-Ⅲ plays an important role in antiviral, immunomodulatory, antitumor, suppression of autoimmune diseases, allergic asthma, as well as antibacterial and antifungal. We elaborate here IFN-Ⅰ and IFN-Ⅲ in terms of classification, sequence homology and …

The unexpected discovery of a novel family of antiviral mediators, type III IFNs or IFN-λs, challenged the widely accepted primacy of type I IFNs in antiviral immunity; and it is now well recognized that the IFN-λ-based antiviral system plays a major role in antiviral protection of epithelial barriers.

2015年8月8日 · The most recently described member of the IFN family, type III IFN shares common anti-viral functions and activation of JAK-STAT signal transduction with type I IFN. However, responses to type III IFN are more limited, due to restricted receptor expression .

2020年7月1日 · III型干扰素（Type III interferon，IFN-III）是近16年发现的新型干扰素，其诱导过程及生物学功能与I型干扰素（Type I interferon，IFN-I）相似，在抗病毒、免疫调节、抗肿瘤、抑制自身免疫病、抑制过敏性哮喘以及抗细菌和真菌等方面具有重要作用。