2024年12月25日 · IFITM1 (Interferon Induced Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with IFITM1 include Influenza and West Nile Virus. Among its related pathways are Cytokine Signaling in Immune system and …

IFITM1 acts through the negative regulatory effect of CAV1 on the EGFR pathway and thus affects the EMT signature and migration (164, 183). IFITM1 was defined as a tight junction protein in hepatocytes, in which it interacts with CD81 and occludin to block hepatitis C virus entry.

IFITM1 could be a novel metastasis-promoting gene that enhances the metastatic phenotype in ovarian cancer via epigenetic transcriptional regulation. IFITM1 is a potential valuable addition to immunohistochemical panels used in the diagnosis of cellular mesenchymal uterine tumors.

Interferon-induced transmembrane protein 1 (IFITM1) is a member of the IFITM family that is associated with some acute-phase cytokine-stimulated response. Recently, we demonstrated that IFITM1 was significantly upregulated in the injured spinal cords at the mRNA level.

2024年4月22日 · The function of interferon-induced transmembrane protein-1 (IFITM1) in EBV infection of ECs remains elusive. Here we report that IFITM1 inhibits EphA2-mediated EBV entry into ECs.

2012年12月14日 · Most vertebrate animals have two or more IFITM genes. The human IFITM locus is located on chromosome 11 and is composed of four functional genes: IFITM1, IFITM2, IFITM3 and IFITM5.

2021年7月28日 · Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show...

At least three human IFITM proteins—IFITM1, IFITM2, and IFITM3—have antiviral activities. These activities limit infection in cultured cells by many viruses, including dengue virus, Ebola virus, influenza A virus, severe acute respiratory syndrome coronavirus, and West Nile virus.

Interferon-inducible transmembrane (IFITM) proteins are a family of small homologous proteins, localized in the plasma and endolysosomal membranes, which confer cellular resistance to many viruses.

2024年2月5日 · IFITM1 expression determines extracellular vesicle uptake in colorectal cancer. Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression.