Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD …

2024年12月25日 · IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) is a Protein Coding gene. Diseases associated with IDH2 include D-2-Hydroxyglutaric Aciduria 2 and Multiple …

IDH1/2是人类癌症中最常发生突变的代谢基因，干扰细胞代谢和表观调节，促进癌症发生。 【解释】： IDH1和IDH2编码异柠檬酸脱氢酶1和2，催化异柠檬酸氧化脱羧成ɑ-酮戊二酸（α-KG） …

IDH是三羧酸循环的限速酶，能够催化异柠檬酸使之氧化脱羧生成α-KG和CO2。 由IDH催化的这一反应不仅是TCA循环上不可缺少的一个环节，还是细胞内NADPH/NADH等物质的重要来源之 …

2022年8月31日 · Here's what to know about the IDH2 mutation, how it is affiliated with a few different conditions, and what it means for treatments. The IDH2 mutation has been detected …

The IDH2 gene provides instructions for making an enzyme called isocitrate dehydrogenase 2. This enzyme is found in mitochondria, which are the energy-producing centers within cells.

2023年9月29日 · 在嵌合抗原受体（CAR）T细胞的离体培养过程中抑制IDH2可诱导其形成记忆T细胞的特征，并增强其对黑色素瘤、白血病和多发性骨髓瘤的抗肿瘤活性。 抗原刺激和扩增 …

IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF-kappaB signaling to promote colorectal cancer progression. IDH2 stabilizes HIF-1alpha …

2023年1月2日 · 异柠檬酸脱氢酶（isocitrate dehydrogenase，IDH）是三羧酸循环中催化异柠檬酸转化为α-酮戊二酸（α-KG）的关键代谢酶，也是急性髓细胞白血病（acute …

IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF-κB signaling to promote colorectal cancer progression. He X, Wu N, Li R, Zhang H, Zhao Y, …