Hypoxia-Response Element (HRE)–Directed Transcriptional …
Upon hypoxia, HIF-1α is upregulated and HIF-1 complex binds to the hypoxia-response element (HRE) of the gene promoter for transactivation. Cobalt (Co), an essential metal for the formation of vitamin B12, mimics the hypoxia condition in the cell culture system activating the HIF-1 …
仅显示来自 pmc.ncbi.nlm.nih.gov 的搜索结果Transcriptional Regulation b…
The cellular response to oxygen deprivation is governed largely by a family of …
Hypoxia response elements …
Hypoxia-inducible factor-1 (HIF-1) has been shown to mediate the transcriptional …
Transcriptional Regulation by Hypoxia Inducible …
The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the …
Hypoxia response elements - PubMed
Hypoxia-inducible factor-1 (HIF-1) has been shown to mediate the transcriptional activation of its target genes in response to oxygen concentration, most likely via a pathway involving a …
- Hypoxia Response Element 的研究
Cellular adaptation to hypoxia through …
2020年3月6日 · HIFs bind to hypoxia response elements in the promoter regions of a large number of targets, including those involved in cell survival, angiogenesis, glycolysis and …
Hypoxia response elements (HREs) | MedChemExpress
Definition: Hypoxia response elements (HREs)is composed of 5'-TACGTG-3' sites and some variable side sequences due to the activation of HIF-1α. In the process of hypoxic transcription …
Tumour hypoxia in driving genomic instability and tumour evolution
3 天之前 · HIF1 consists of α and β subunits, which heterodimerize and bind to DNA at hypoxia response elements in promoter or enhancer regions of numerous genes to upregulate their …
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Direct inhibition of tumor hypoxia response with synthetic
2024年8月30日 · Under hypoxia, STR22 globally suppresses HIF1α binding to HRE-containing promoters and enhancers, inhibits hypoxia-induced gene expression and blocks …
Hypoxia Response Elements in the Aldolase A, Enolase 1, and …
1996年12月20日 · In this paper we characterize hypoxia response elements in the promoters of the ALDA, ENO1, and Ldha genes. We demonstrate that HIF-1 plays an essential role in …
477. Effects of Hypoxia Response Element and DNA …
Hypoxia response element (HRE) sequence is recognized by hypoxia-inducible factor (HIF), which is the main transcription factor recruited in hypoxia. Transport of plasmid with HIF or DTS in normoxia and hypoxia is not clear and we report …
Hypoxia response elements - PubMed
MeSH terms Animals Cell Hypoxia / physiology Humans Hypoxia-Ischemia, Brain / metabolism Hypoxia-Ischemia, Brain / physiopathology Response Elements / physiology*