It has been described as a lysosomal hyaluronidase which is active at a pH below 4 and specifically hydrolyzes high molecular weight hyaluronan. It has also been described as a GPI-anchored cell surface protein which does not display hyaluronidase activity but does serve as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus.

2024年12月25日 · HYAL2 (Hyaluronidase 2) is a Protein Coding gene. Diseases associated with HYAL2 include Hyal2 Deficiency and Cleft Lip And Palate-Craniofacial Dysmorphism-Congenital Heart Defect-Hearing Loss Syndrome. Among its related pathways are Glycosaminoglycan metabolism and Metabolism.

Hyaluronidase 2 (HYAL2) is a membrane-anchored protein that is proposed to initiate the degradation of hyaluronan (HA) in the extracellular matrix. The distribution of HYAL2 in tissues, and of HA in tissues lacking HYAL2, is largely unexplored despite the importance of HA metabolism in several disea …

2023年9月21日 · Hyaluronidase-2 (HYAL2) is proposed to act as a hyaluronidase enzyme, catalyzing the degradation of the high-molecular-weight glycosaminoglycan hyaluronan. HYAL2 undergoes complex post-translational modification before achieving its final topology as a mature GPI-anchored cell surface glycoprotein.

Hyaluronidase (HYAL)-2 is a weak, acid-active, hyaluronan-degrading enzyme broadly expressed in somatic tissues. Aberrant HYAL2 expression is implicated in diverse pathology. However, a significant proportion of HYAL2 is enzymatically inactive; thus ...

2017年2月14日 · Hyaluronan (HA) is required for endothelial-to-mesenchymal transition and normal heart development in the mouse. Heart abnormalities in hyaluronidase 2 (HYAL2)–deficient (Hyal2−/−) mice and humans suggested removal of HA is also important for normal heart development.

2015年10月29日 · Hyaluronidase 2 (HYAL2) is a membrane-anchored protein that is proposed to initiate the degradation of hyaluronan (HA) in the extracellular matrix. The distribution of HYAL2 in tissues, and of HA in tissues lacking HYAL2, is largely unexplored despite the importance of HA metabolism in several disease processes.

2017年1月12日 · HYAL2, encoding hyaluronidase 2, degrades extracellular hyaluronan, a critical component of the developing heart and palatal shelf matrix. Transfection assays demonstrated that the gene mutations destabilize the molecule, dramatically reducing HYAL2 protein levels.

These studies confirm an association between HYAL2 alterations and syndromic cleft lip/palate, provide experimental evidence for the pathogenicity of missense alleles, enable further insights into the pathomolecular basis of the disease, and delineate the core and variable clinical outcomes of the c …

Hyaluronidases degrade hyaluronic acid (HA), a glycosaminoglycan present in the extracellular matrix of vertebrates. Hyaluronidase-2 exhibits very low hyaluronidase activity (Lepperdinger et al., 1998; Rai et al., 2001).