Protein HtrA2, also known as Omi, is a mitochondrially-located serine protease. The human protein Serine protease HTRA2, mitochondrial is 49kDa in size and composed of 458 amino acids.

2024年12月25日 · HTRA2 (HtrA Serine Peptidase 2) is a Protein Coding gene. Diseases associated with HTRA2 include 3-Methylglutaconic Aciduria, Type Viii and Parkinson Disease 13, Autosomal Dominant. Among its related pathways are …

2008年1月4日 · Here, we review the current knowledge of HtrA2/Omi biology and discuss the signaling pathways that underlie its mitochondrial and apoptotic functions from an evolutionary perspective.

2024年3月30日 · HtrA2, a mitochondrial protease that is associated with Parkinson’s disease, is playing an important role in the cleavage of DELE1 and the activation of HRI-directed integrated stress response ...

2023年6月7日 · High-temperature requirement serine protease A 2 (HtrA2) is known to be involved in growth, unfolded protein response to stress, apoptosis, and autophagy. However, whether HtrA2 controls inflammation and immune response remains elusive.

2022年10月28日 · Here we have identified a unique enzyme, HtrA2, localized in the parasite mitochondria; we show that this enzyme plays a dual role in maintenance of parasite mitochondria under normal conditions, as well as regulation of PCD under cellular stress conditions.

Here we report that a serine protease called HtrA2/Omi is released from mitochondria and inhibits the function of XIAP by direct binding in a similar way to Smac.

2025年2月9日 · HtrA2 expression was a predictor for sensitivity to chemotherapy, and could be a candidate of molecular target in the treatment of high-grade serous ovarian cancers. This study shows that PARK13 and PINK1 are subcellular-specific, but dynamic, proteins with a reciprocal molecular relationship.

HGNC Approved Gene Symbol: HTRA2. The HTRA2 gene encodes a serine protease that localizes to the mitochondrial intermembrane space. Following apoptotic stimuli, HTRA2 can expose an inhibitor of apoptosis protein (IAP) binding motif, thus mediating cell death, or can mediate cell death via its serine protease activity (Suzuki et al., 2001).

2021年3月2日 · Title: HtrA2 regulates α-Synuclein-mediated mitochondrial reactive oxygen species production in the mitochondria of microglia. A new function for the serine protease HtrA2 in controlling radiation-induced senescence in cancer cells.