Protein HtrA2, also known as Omi, is a mitochondrially-located serine protease. The human protein Serine protease HTRA2, mitochondrial is 49kDa in size and composed of 458 amino …

2024年12月25日 · HTRA2 (HtrA Serine Peptidase 2) is a Protein Coding gene. Diseases associated with HTRA2 include 3-Methylglutaconic Aciduria, Type Viii and Parkinson Disease …

2008年1月4日 · Here, we review the current knowledge of HtrA2/Omi biology and discuss the signaling pathways that underlie its mitochondrial and apoptotic functions from an evolutionary …

2024年3月30日 · HtrA2, a mitochondrial protease that is associated with Parkinson’s disease, is playing an important role in the cleavage of DELE1 and the activation of HRI-directed …

2023年6月7日 · High-temperature requirement serine protease A 2 (HtrA2) is known to be involved in growth, unfolded protein response to stress, apoptosis, and autophagy. However, …

2022年10月28日 · Here we have identified a unique enzyme, HtrA2, localized in the parasite mitochondria; we show that this enzyme plays a dual role in maintenance of parasite …

Here we report that a serine protease called HtrA2/Omi is released from mitochondria and inhibits the function of XIAP by direct binding in a similar way to Smac.

2025年2月9日 · HtrA2 expression was a predictor for sensitivity to chemotherapy, and could be a candidate of molecular target in the treatment of high-grade serous ovarian cancers. This …

HGNC Approved Gene Symbol: HTRA2. The HTRA2 gene encodes a serine protease that localizes to the mitochondrial intermembrane space. Following apoptotic stimuli, HTRA2 can …

2021年3月2日 · Title: HtrA2 regulates α-Synuclein-mediated mitochondrial reactive oxygen species production in the mitochondria of microglia. A new function for the serine protease …