Dec 25, 2024 · HTR7 (5-Hydroxytryptamine Receptor 7) is a Protein Coding gene. Diseases associated with HTR7 include Migraine With Or Without Aura 1 and Alcohol Dependence. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Monoamine GPCRs.

Jan 25, 2024 · 5-羟色胺 (5-hydroxytryptamine, 5-HT, 又称为血清素) 是一种单胺类神经递质，在中枢神经系统和外周组织中调节神经和其他生物功能。 前期研究表明，5-HT对肿瘤进展具有刺激作用，还可以通过作用于浸润在肿瘤微环境中的免疫细胞来发挥生物学效应。 近年来研究发现一种新的翻译后修饰—— 5-羟色胺化反应 [1]。 CD8+T细胞表达血清素激活系统的组分，然而， 5-羟色胺化修饰是否参与CD8+T细胞的抗肿瘤免疫尚不清楚。

The 5-HT 7 receptor is encoded by the HTR7 gene, which in humans is transcribed into 3 different splice variants. [9]

Oct 25, 2024 · Enteric serotonergic neurons promote gut-homing, retention and activation of intestinal plasmacytoid dendritic cells (pDC). Mechanistically, this neuro-immune crosstalk is achieved through a...

HTR7 is a susceptibility gene for schizophrenia in this Japanese group. The decrease in affinity of 5-HT and other 5-HT receptor agonists at the (Thr92Lys) h5-HT7 receptor may be associated with changes of sleep physiology and of actions of new 5-HT7 receptor agonists designed to treat circadian dysregulation.

Jan 4, 2025 · HTR7 is a direct target of miRNA-29a. MiRNA-29a plays a role in visceral hyperalgesia pathogenesis of IBS. Title: MiRNA-29a modulates visceral hyperalgesia in irritable bowel syndrome by targeting HTR7.

由该基因编码的血清素受体属于 G 蛋白偶联受体超家族，该基因是参与自闭症和其他神经精神疾病的候选位点。 已经鉴定出三种剪接变体，它们编码的蛋白质的羧基末端长度不同。 [RefSeq 提供，2008 年 7 月] The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions.

② 从机制层面来看，这种神经与免疫系统的相互作用是通过5-羟色胺-5-羟色胺受体7（htr7）信号轴来实现的。 该信号轴在促进肠道中pDC介导的IgD+ 前体细胞向IgA+ B细胞分化方面发挥着关键作用。

Oct 28, 2024 · ② 从机制层面来看，这种神经与免疫系统的相互作用是通过5-羟色胺-5-羟色胺受体7（htr7）信号轴来实现的。 该信号轴在促进肠道中pDC介导的IgD+ 前体细胞向IgA+ B细胞分化方面发挥着关键作用。

Complete sequencing and characterization of 21,243 full-length human cDNAs. The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).