2024年12月25日 · HOXD10 (Homeobox D10) is a Protein Coding gene. Diseases associated with HOXD10 include Vertical Talus, Congenital and Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding.

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene. [5] This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2.

Homeobox D10, a tumor suppressor, inhibits the proliferation and migration of esophageal squamous cell carcinoma. The results indicated that completely different sets of transcription factors coregulate HOXA4 and HOXD10 (but not HOXA9) and their expression-correlated genes.

2014年7月10日 · HOX gene expression is altered in many cancers; previous microarray revealed changes in HOX gene expression in head and neck squamous cell carcinoma (HNSCC), particularly HOXD10. HOXD10...

Title: Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway. Results show that HOXD10 promoter is hypermethylated in papillary thyroid cancer (PTC) tissues and its mRNA expression decreased.

2022年11月1日 · HOXD10 positively augmented miR-381 transcription by binding to its promoter and suppressed the proliferation, metastasis, and colony formation of OC cells (Hsu et al., 2018). Additionally, HOXD10 targets IGFBP3 promoter and suppresses cell invasion, thus improving the prognosis of GC patients (Wang et al., 2012, Xue et al., 2013).

Using transcription factor activity analysis, we identified the homeobox transcription factor HOXD10 to be specifically activated at early time points after VEGFR-3 stimulation, and to regulate expression of immediate early transcription factors, including NR4A1.