HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation ...

2024年12月25日 · HLA-DOA (Major Histocompatibility Complex, Class II, DO Alpha) is a Protein Coding gene. Diseases associated with HLA-DOA include Hirata Disease. Among its related pathways are TCR Signaling (Qiagen) and Immune response NFAT in immune response.

HLA-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies. HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity; results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in ...

HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.

hla-ii类基因包括hla-d家族，主要有hla-dp、hla-dq和hla-dr等，主要分布于b淋巴细胞、巨噬细胞和树突状细胞等专职抗原提呈细胞表面。 HLA-III类基因 大约包含75个基因，大多数功能不明。

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation ...

Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.

2024年6月1日 · HLA class II antigen presentation is modulated by the activity of the peptide editor HLA-DM and its antagonist HLA-DO, with their interplay controlling the peptide repertoires presented by normal and malignant cells. The role of these molecules in allogeneic hematopoietic cell transplantation (alloHCT) is poorly investigated.

hla-doa与hla-dob形成异二聚体。 该异二聚体HLA-DO存在于B细胞的溶酶体中，并调节HLA-DM介导的MHC II类分子上的肽加载。 与经典的HLA II类分子相比，该基因在蛋白质水平上的序列变异非常小。

The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.