2024年12月25日 · HJURP (Holliday Junction Recognition Protein) is a Protein Coding gene. Diseases associated with HJURP include Luminal Breast Carcinoma A and Lung Cancer . Among its related pathways are Packaging Of Telomere Ends and Cell Cycle, Mitotic .

Holliday Junction Recognition Protein (HJURP) is a highly specialized mitogenic protein that is a chaperone protein of histone H3. The HJURP gene is located on chromosome 2q37.1 and is involved in nucleosome composition in the mitotic region, forming a three-dimensional crystal structure with Centromere Protein A (CENP-A) and the histone 4 complex.

2009年5月1日 · In the absence of an underlying DNA sequence, it is still unclear how CENP-A deposition at centromeres is determined. Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified HJURP.

2019年9月6日 · HJURP is the CENP-A chaperone, which associates with Mis18α, Mis18β, and M18BP1 to target centromeres and deposit new CENP-A. How these proteins interact to promote CENP-A deposition...

2024年1月26日 · Here, we demonstrate that HJURP is recruited to DSBs through a mechanism requiring chromatin PARylation and promotes epigenetic alterations that favor the execution of DNA repair. Incorporation...

2025年2月8日 · HJURP is a prognostic biomarker for clear cell renal cell carcinoma and is linked to immune infiltration. Hypomethylation-driven overexpression of HJURP promotes progression of hepatocellular carcinoma and is associated with poor prognosis.

2009年5月1日 · We conclude that HJURP is a key factor for CENP-A deposition and maintenance at centromeres. The centromere is the highly specialized chromosomal locus that ensures the delivery of one copy of each chromosome to each daughter cell at cell division.

Holliday Junction Recognition Protein (HJURP) is identified as a sort of centromeric protein that plays a pivotal role in the assembly and maintenance of histone H3-like variant CENP-A 5, and it helps the recruitment of CENP-C and mediates chromosome segregation and cell division 6.

2023年3月21日 · Holliday Junction Recognition Protein (HJURP) is a highly specialized mitogenic protein that is a chaperone protein of histone H3. The HJURP gene is located on chromosome 2q37.1 and is involved in nucleosome composition in the mitotic region, forming a three-dimensional crystal structure with Centromere Protein A (CENP-A) and the histone 4 complex.

2022年4月22日 · We observed significantly increased HJURP expression levels in triple-negative breast cancer compared to other subtypes. HJURP could affect the level of ubiquitination modification of YAP1...