Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 that is encoded by the HIF1A gene. [5] [6] [7] The Nobel Prize in Physiology or Medicine 2019 was awarded for the discovery of HIF.

Dec 25, 2024 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Pheochromocytoma and Retinal Ischemia. Among its related pathways are Signaling by PTK6 and Autodegradation of the E3 ubiquitin ligase COP1.

Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. This review summarizes the role and regulation of the HIF-1 α in cancer and recent therapeutic approaches targeting this important pathway. 1. The role of HIF-1 α pathway in cellular adaptation to hypoxic stress.

Recently, it has been identified that hypoxia-inducible factor-1 alpha (HIF-1α) is a major transcriptional regulatory factor that responds to hypoxic environments and modulates the expression of many genes in the organism and is closely associated with the biological behavior of malignant tumors. 1,2 Importantly, HIF-1α is commonly highly expres...

Feb 15, 2008 · In keeping with the complexity of the hypoxic response, three principal isoforms of HIF- α exist (HIF-1 α, HIF-2 α and HIF-3 α). All are encoded by distinct gene loci and further diversity is...

HIF1A promotes miR-210/miR-424 transcription to modulate the angiogenesis in HUVECs and HDMECs via sFLT1 under hypoxic stress. HIF-1alpha and Nrf2 regulates hypoxia induced overexpression of DDAH1 through promoter activation in prostate cancer.

Feb 29, 2004 · Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a constitutively expressed HIF-1beta subunit and one of three subunits (HIF-1alpha, HIF-2alpha or HIF-3alpha).

HIF1A driven transcriptional response in hypoxia depends on epigenetic control at DNA methylation status of gene regulatory regions. Furthermore, low oxygen levels generate HIF1A-dependent or HIF1A-independent signatures, able to stratify patients according to risk categories.

Jun 8, 2015 · 1a (HIF1a), a transcription factor (TF) activated by low oxygen, mediates a pro-proliferative response during cardiac develop-ment. In well-perfused tissues, HIF1a subunits are hydroxylated and targeted for proteasomal degradation via VHL-mediated ubiquitination. Hypoxia ([O 2]< 5%) disrupts HIF1a ubiquitina-

We hypothesized that intermittent hypoxia (IH) modeling obstructive sleep apnea would worsen hepatic steatosis and fibrosis in murine NAFLD, via HIF-1. Mice with hepatocyte-specific deletion of Hif1a (Hif1a-/-hep) and wild-type (Hif1aF/F) controls were fed a high trans -fat diet to induce NAFLD with steatohepatitis.