HIF1α and HIF2α are considered to be the canonical inducible activators of the response to hypoxia while HIF3α is less well understood. HIF1α is widely expressed, while HIF2α is expressed in a more restricted set of tissues (11, 13).

Sep 5, 2024 · Targeting HIF-2α holds great promise for effectively addressing solid tumors associated with aberrant oxygen-sensing pathways and hypoxia mechanisms, offering broad application prospects. In this review, we provide an overview of recent advancements (2009–2024) in HIF-2α modulators such as inhibitors, agonists, and degraders for cancer …

Hypoxia-inducible factor-2 alpha (HIF-2⍺) is a transcription factor that induces target genes responsible for the hypoxic stress response. Hypoxia enhances cancer cell resistance to …

The transcriptional response to hypoxia is primarily mediated by two hypoxia-inducible factors – HIF-1α and HIF-2α. While these proteins are highly homologous, increasing evidence suggests they have unique transcriptional targets and differential ...

Mar 4, 2023 · Here we briefly recapitulate the molecular rationale for HIF2α blockade in tumors and review available preclinical and clinical data, elaborating on mutations that might be particularly sensitive to this approach.

Jan 18, 2025 · HIF-1 and HIF-2 are well known and widely described. Although these proteins share a high degree of homology, HIF-1 and HIF-2 have non-redundant roles in cancer. In this review, we summarize the similarities and differences between HIF-1α and HIF-2α in their structure, expression, and DNA binding.

Park S.-K., et al. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1a (HIF-1a): role of cytoplasmic trapping of HIF-2a.

Nov 5, 2020 · Mice with a neuro-specific knockout of Hif-2α showed a reduction of pyramidal neurons in the retrosplenial cortex (RSC), a brain region responsible for a range of cognitive functions, including...

Mar 1, 2001 · Hypoxia inducible factor 1a and 2a (HIF-1a and HIF-2a) are key proteins regulating cellular response to hypoxia. Because the efficacy of photodynamic therapy (PDT) is dependent on the presence of oxygen, the assessment of HIF-1a and HIF-2a expression may be of value in predicting clinical response t …

Jul 18, 2023 · HIF-1a and HIF-2a upstream and downstream pathways promoting cancer. HIF-1a expression varies with oxygen level in the cellular environment while HIF-2a is constitutively expressed and has some known oncogenic effects.