Recent progress in the development of hypoxia-inducible factor 2α (HIF ...
2024年9月5日 · Hypoxia-inducible factor 2α (HIF-2α) is a critical transcription factor that regulates cellular responses under hypoxic conditions. In situations of insufficient oxygen supply or …
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting ...
Activation of hypoxia-inducible factor subunit 2 alpha (HIF2α) is a frequent feature of cancers. Preclinical and clinical data suggest HIF2α dependence in several cancers with disruption of …
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting ...
2023年3月4日 · Here we briefly recapitulate the molecular rationale for HIF2α blockade in tumors and review available preclinical and clinical data, elaborating on mutations that might be …
Biology of Hypoxia-Inducible Factor-2α in Development and …
HIF-2α transcriptional targets include genes involved in erythropoiesis, angiogenesis, metastasis, and proliferation. Therefore, HIF-2α contributes significantly to both normal physiology as well …
HIF-1 and HIF-2: working alone or together in hypoxia? - PMC
HIF-1α was the original HIF isoform identified by affinity purification using oligonucleotides from the EPO locus (1), while HIF-2α and HIF-3α were identified by homology searches or screens …
FDA Approves Merck’s Hypoxia-Inducible Factor-2 Alpha (HIF …
2021年8月13日 · WELIREG is the first HIF-2α inhibitor therapy approved in the U.S. As an inhibitor of HIF-2α, WELIREG reduces transcription and expression of HIF-2α target genes …
Novel cancer treatment paradigm targeting hypoxia-induced …
2023年7月18日 · HIF-1a and HIF-2a upstream and downstream pathways promoting cancer. HIF-1a expression varies with oxygen level in the cellular environment while HIF-2a is …
Hypoxia-inducible factor-2α is crucial for proper brain development
2020年11月5日 · The hypoxia-inducible factor as a transcription factor conducts several hundred target genes during brain development and maintains normal function of the adult brain by …
HIF-2α is indispensable for regulatory T cell function - PubMed
2020年10月6日 · We show crosstalk between HIF-2α and HIF-1α, and that HIF-2α represses HIF-1α expression. HIF-1α is upregulated in HIF-2α-KO Treg cells and further deletion of HIF-1α …
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early ...
2001年3月1日 · Hypoxia inducible factor 1a and 2a (HIF-1a and HIF-2a) are key proteins regulating cellular response to hypoxia. Because the efficacy of photodynamic therapy (PDT) …