Dec 25, 2024 · HHEX (Hematopoietically Expressed Homeobox) is a Protein Coding gene. Diseases associated with HHEX include Maturity-Onset Diabetes Of The Young and Heart Defects, Congenital, And Other Congenital Anomalies. Among its related pathways is …

关于 hhex Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:92,689,955-92,695,647 (from NCBI) This gene has 4 transcripts (splice variants) and 116 orthologues.

Hhex binds to the Cdkn2a locus and directly interacts with the Polycomb-repressive complex 2 (PRC2) to enable H3K27me3-mediated epigenetic repression; Data suggest that Hhex is a novel regulator of c-Myc function that limits c-Myc activity in transformed cells.

Feb 8, 2025 · Hematopoietically-expressed homeobox protein HHEX regulates adipogenesis in preadipocytes. Hhex regulates murine lymphoid progenitor survival independently of Stat5 and Cdkn2a. The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development.

HHEX的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为该基因编码的同源框转录因子家族，其中许多都涉及发育过程中的一员。在特定造血谱系表达表明该蛋白可能在造血细胞分化的作用。 [由RefSeq的，2008年7月提供]

Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene and also known as Proline Rich Homeodomain protein PRH. [5] [6] [7] This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes.

Hhex inhibits cell migration via regulating RHOA/CDC42-CFL1 axis in human lung cancer cells.

Here, using a combination of genetic and molecular approaches, we identify the transcription factor hematopoietically expressed homeobox (HHEX) as an upstream regulator of VEGFC, FLT4, and PROX1 during angiogenic sprouting and lymphatic formation in vertebrates.

Jul 13, 2018 · Here, using a combination of genetic and molecular approaches, we identify the transcription factor hematopoietically expressed homeobox (HHEX) as an upstream regulator of VEGFC, FLT4, and PROX1...

Jul 13, 2018 · Here, using a combination of genetic and molecular approaches, we identify the transcription factor hematopoietically expressed homeobox (HHEX) as an upstream regulator of VEGFC, FLT4, and PROX1 during angiogenic sprouting and lymphatic formation in vertebrates.