Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met.

2024年12月25日 · HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

Hepatocyte Growth Factor (HGF) is a polypeptide that promotes cell growth, motility, and morphogenesis, and acts as a cell survival factor in the liver. It is synthesized and secreted as a precursor that is processed into a biologically active form.

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases.

Transforming growth factor-beta (TGF- β) and hepatocyte growth factor (HGF) are inflammatory cytokines which function as key regulators of immunological homeostasis and inflammatory responses. They have been linked to inflammatory bowel diseases (IBD).

HGF is a potent inhibitor of cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 through both autocrine and paracrine Epstein-Barr virus-independent pathways. HGF increased the motogenesis and invasiveness of hepatoblasts, but not of human adult hepatocytes, via phosphorylation of extracellular signal-regulated kinase (ERK) 1/2.

Hepatocyte growth factor (HGF), also knownasscatter factor (SF),is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on …

2015年4月1日 · Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases.

Hepatocyte growth factor (HGF) is a pleiotropic cytokine composed of an α-chain and a β-chain, and these chains contain four kringle domains and a serine protease-like structure, respectively. The receptor for HGF was identified as the c-met proto-oncogene product of transmembrane receptor tyrosine …

The Hepatocyte Growth Factor (HGF) was originally identified as a soluble factor promoting hepatocyte growth and liver regeneration . In a parallel way a Scatter Factor (SF) was identified as cytokine secreted by fibroblast promoting dissociation and motility of epithelial cells in culture .

It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met.

2 天之前 · Hepatocyte growth factor (HGF) is produced by various types of cells. It has a wide distribution of tissues and can participate in the maintenance and renewal of vital organs such as liver, lung, and kidney, then promote the regeneration of these organs.

2025年2月8日 · The gene expression of hepatocyte growth factor (HGF) increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates HGF protein expression

2022年3月17日 · Hepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine that acts on various epithelial cells to regulate cell growth, movement and morphogenesis, and tissue regeneration of injured organs.

Hepatocyte growth factor (HGF, also known as scatter factor) is one example of such a pleiotropic factor which is able to induce a variety of responses in development and in pathological...

2015年4月1日 · Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases.

Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and a variety of other cells, including endothelial and epithelial cells, melanocytes, and keratinocytes. It also mediates epithelial morphogenesis.

2022年3月16日 · Hepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine that acts on various epithelial cells to regulate cell growth, movement and morphogenesis, and tissue regeneration of injured organs. HGF is sequestered by heparin-like protein in its inactive form and is widespread in the extracellular matrix of most tissues.

Hepatocyte growth factor/scatter factor (HGF/SF) is an important humoral mediator of liver regeneration and related to molecular mechanisms of hepatocarcinogenesis via paracrine system involving its cellular receptor, c-met.