Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) also known as cardiovascular helix-loop-helix factor 1 (CHF1) is a protein that in humans is encoded by the HEY2 gene. [5][6]

2025年1月2日 · Induced Hey2 expression in zebrafish hearts or mammalian cardiomyocytes impairs mitochondrial respiration, accompanied by elevated ROS, resulting in cardiomyocyte …

2024年12月25日 · HEY2 (Hes Related Family BHLH Transcription Factor With YRPW Motif 2) is a Protein Coding gene. Diseases associated with HEY2 include Familial Thoracic Aortic …

2018年4月10日 · Gene expression profiling and ChIP-seq identifies HEY2, a NOTCH-dependent bHLH class transcription factor 15, as a potential downstream mediator of NKX2-5. …

2025年1月2日 · Knockdown of Hey2 in adult mouse hearts protects against doxorubicin-induced cardiac dysfunction. These studies reveal an evolutionarily conserved HEY2/HDAC1 …

2018年2月8日 · We found that Hey2 is expressed in the endocardial cells of the atrioventricular canal and the outflow tract, as well as at the base of trabeculae, in addition to the reported …

2025年2月20日 · Genetic variation of HEY2 is associated with Brugada syndrome through alteration of ion channel expression in the cardiac ventricular wall. Individuals with HEY2 …

2017年6月21日 · The HEY2 locus harbors common variants with a moderate effect size (odds ratio of 1.6 per risk allele) 2 and should be regarded as a modifier of BrS risk among other …

To determine the expression pattern and the regulation of Hey2, we used novel methods including RNAscope and a Hey2CreERT2 knockin line to precisely determine the spatiotemporal …

HEY2 is a basic helix-loop-helix (bHLH) transcription factor that plays an important role in the developing mammalian heart and brain. In humans, nonsynonymous mutations in HEY2 have …