HES1 influences the maintenance of certain stem cells and progenitor cells. Specifically, HES1 influences the timing of differentiation by repressing bHLH activators, and determines binary …

Dec 25, 2024 · HES1 (Hes Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with HES1 include Alagille Syndrome 1 and Strawberry Gallbladder. …

Hairy and enhancer of split-1 (HES1) is a basic helix-loop-helix transcription factor that is a key regulator of development and organogenesis. However, little is known about the role of HES1 …

Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, …

Hes1, a canonical Notch target and transcriptional repressor, is responsible for sustaining IKK activation in T-ALL. Hes1 exerts its effects by repressing the deubiquitinase CYLD, a negative …

Hes1 Regulates Hedgehog Signaling via Direct Binding to Gli1. As previous work has suggested the potential for crosstalk between the Notch and Hedgehog signaling cascades , we focused …

Hairy and enhancer of split (HES1), a transcription factor whose expression is initiated by the Notch signaling pathway, is a repressor of cell cycle inhibitors. We hypothesize that with the …

In this review, we focus on how a dynamic gene, Hes1, is involved in neurogenesis with the view of its regulation and functional implications. Initially, we have reviewed the immense functional …

Oct 2, 2014 · Hes1 inhibits proliferation and differentiation of neural precursor cells. Hes1 may represent a negative regulator of adult neurogenesis post-TBI. Hes1 knockdown improves …

Jan 30, 2014 · HES1 belongs to a family of basic helix-loop-helix (bHLH) proteins that are essential for neurogenesis, myogenesis, hematopoiesis, and sex determination. HES1 is a …

Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, …

Aug 1, 2016 · HES1 is regulated by the NOTCH signalling pathway as well as the wnt and hedgehog pathways. HES1 plays an important role in T cell development and cancer. HES1 …

A transcriptional regulator, Hes1, plays crucial roles in the control of differentiation and proliferation of neuronal, endocrine, and T-lymphocyte progenitors during development. …

The transcriptional repressor Hairy Enhancer of Split 1 (HES1) plays an essential role in the development of many organs by promoting the maintenance of stem/progenitor cells, …

HES1 is a transcriptional repressor that inhibits its own transcription and causes HES1 to oscillate with a 2–3h periodicity in NSCs. In turn, the proneural gene Ascl1, which is a downstream …

Mar 10, 2011 · We report that HES1 regulates proapoptotic signals by the novel interacting protein Poly ADP-Ribose Polymerase1 (PARP1) in a cell type–specific manner. Interaction of …

May 30, 2023 · Here, we show that oscillatory Hes1 expression down-regulates the expression of the cyclin-dependent kinase inhibitor p21 (Cdkn1a), which delays cell-cycle progression, and …

Notch target gene Hes1 is regulated by the transforming growth factor-β/bone morphogenetic protein signaling pathway in hepatic stellate cell-T6 cells. A: Western blot analysis of Hes1 …

Jan 1, 2000 · Hes1 is one of the basic helix-loop-helix transcription factors that regulate mammalian CNS development, and its loss- and gain-of-function phenotypes indicate that it …

Feb 26, 2020 · To examine the effect of altered oscillatory dynamics of Hes1, we generated two types of Hes1 knock-in mice, a shortened (type-1) and an elongated (type-2) Hes1 gene, and …