2024年12月25日 · HES1 (Hes Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with HES1 include Alagille Syndrome 1 and Strawberry Gallbladder. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Autodegradation of the E3 ubiquitin ligase COP1.

Hairy and enhancer of split-1 (HES1) is a basic helix-loop-helix transcription factor that is a key regulator of development and organogenesis. However, little is known about the role of HES1 after birth.

Hes1, a canonical Notch target and transcriptional repressor, is responsible for sustaining IKK activation in T-ALL. Hes1 exerts its effects by repressing the deubiquitinase CYLD, a negative IKK complex regulator.

Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.

Hes1 Regulates Hedgehog Signaling via Direct Binding to Gli1. As previous work has suggested the potential for crosstalk between the Notch and Hedgehog signaling cascades , we focused on the upregulation of Hedgehog signaling in response to MRK-003.

2014年10月2日 · Hes1 inhibits proliferation and differentiation of neural precursor cells. Hes1 may represent a negative regulator of adult neurogenesis post-TBI. Hes1 knockdown improves cognitive function of adult mouse following injury.

HES1 is a critical member of the HES protein family, a group of basic helix-loop-helix transcription factors that play a key role in regulating the proliferation and differentiation of stem cells, particularly in the development of the nervous system.

In this review, we focus on how a dynamic gene, Hes1, is involved in neurogenesis with the view of its regulation and functional implications. Initially, we have reviewed the immense functional significance drawn by this maestro during neural development in a context-dependent manner.

2025年1月4日 · HES-1 is a regulator of intracellular signal transduction stimulated by cell adhesion molecules involved in neurite outgrowth. Hes1 can drive GRPs to an astrocyte cell fate at the expense of oligodendrocyte differentiation.

2016年6月20日 · We found that the transcriptional repressor Hes1 suppressed production of CXCL1, a chemokine that is crucial for recruiting neutrophils. Hes1 negatively regulated neutrophil recruitment in vivo...