hERG (the human Ether-à-go-go-Related Gene) is a gene that codes for a protein known as K v 11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply …

2020年6月1日 · We provide in this concise review clear guidelines, based on described examples, illustrating successful optimization process to avoid hERG interactions as cases studies and to …

The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr), which is important for cardiac …

Based on ROC curves the optimal hERG margin thresholds to separate "Known risk of TdP" from "Not Listed" and, QTc prolongation positive from QTc negative were 37- and 50-fold, respectively.

2020年6月1日 · Early detection of hERG toxicity based on several practical tools is reviewed. hERG structure analysis offers new possibilities to predict detrimental binding. A guide for …

The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K(+) channel, Kv11.1, which are expressed in the heart, …

2006年3月22日 · In this review we summarize the normal physiological functions of hERG channels, define the structural basis of their unusual gating and describe how mutations in the …

Blockade of the cardiac ion channel coded by human ether-à-gogo-related gene (hERG) can lead to cardiac arrhythmia, which has become a major concern in drug discovery and development.

2011年5月30日 · Human ether-a-go-go related gene (hERG) potassium (K +) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG conductance …

2014年11月24日 · The human ether-à-go-go related gene (hERG) potassium channel is an obligatory anti-target for drug development on account of its essential role in cardiac …