2012年12月14日 · Most importantly, our research indicates cell-intrinsic roles for NLRP1a-induced pyroptosis in hematopoietic progenitor cells that prevents their proliferation and differentiation to mature cells. Unrestrained pyroptosis in hematopoietic stem and progenitor cells leads to leukopenia at steady state and to anemia and leukopenia during periods of ...

2020年5月7日 · In this issue of Cell Stem Cell, de Laval et al. (2020) describe persistent epigenetic modifications in hematopoietic stem cells following an inflammatory insult with LPS as a mechanism by which immune memory may be established. Higher organisms are constantly interacting with a range of bacteria and viruses.

2020年4月20日 · Recent investigations indicate that hematopoiesis is coregulated by innate immunity signals and by pathways characteristic of the activation of innate immunity cells that also operate in normal...

2022年8月1日 · Several studies reported that Caspase-4/5/11 in the cytoplasm can be used as a sensor to directly bind to the surface LPS of gram-negative bacteria, and mediate the nonclassical pathway of cell pyrolysis and GSDMD is one of the key executive molecules mediating pyrolysis [8].

2024年12月18日 · Hematopoietic stem cell transplantation (HSCT) entails the intravenous infusion of hematopoietic stem and progenitor cells (HSPCs) after conditioning regimens like high-dose chemotherapy and/or radiotherapy.

2015年9月15日 · In this study, we examined the cellular mechanisms underlying murine hematopoietic stem cell (HSC) expansion and common lymphoid progenitor (CLP) depletion in a model of chronic low-dose LPS. Using adoptive-transfer approaches, we show that HSC and CLP sensitivity to chronic LPS depends on hematopoietic-derived, cell subset-autonomous TLR4.

2020年11月17日 · Hematopoietic stem cells (HSCs) replenish all lineages of blood cells throughout the lifespan. During aging, the repopulation capacity of HSCs declined, and aged HSCs display a tendency for myeloid differentiation. Several intrinsic and extrinsic factors have been identified to promote HSCs aging.

2020年7月25日 · While we observed the increase of Caspase-3-GSDME-mediated pyroptosis in Becn1 deficient hematopoietic stem and progenitor cells. Forced expression of the full-length GSDME compromises the function of HSCs. In brief, we identified a novel role of Becn1 in modulating HSCs by regulating pyroptosis, but not through autophagy. This study provides a ...

Multiple cell death pathways are programmed in hematopoietic stem cells (HSCs). HSCs are protected by unique prosurvival mechanisms from their unnecessary loss through apoptosis. HSCs are vulnerable to certain types of programmed necrosis. Activation of programmed cell death pathways can affect HSC function without causing cell death.

2020年12月8日 · GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs). While, how GSDME-mediated pyroptosis regulates HSCs remains unknown.