Helicases are a class of enzymes that are vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor proteins that move directionally along a nucleic double helix, separating the two hybridized nucleic acid strands (hence helic- + -ase), via the energy gained from ATP hydrolysis.

Helicases are enzymes that bind and may even remodel nucleic acid or nucleic acid protein complexes. There are DNA and RNA helicases. DNA helicases are essential during DNA replication because they...

Helicases are ubiquitous nanometric molecular motors involved in every step of nucleic acid (NA) metabolism and are present in nearly every living branch. They are NA-dependent NTPases that convert chemical energy from nucleoside triphosphates (NTP, mainly ATP) binding and hydrolysis to mechanical energy.

Because of their essential function, helicases are ubiquitous and evolutionary conserved proteins. This chapter briefly highlights helicase structure and activities and provides examples of the helicases involved in nucleic acid metabolism.

2024年10月24日 · DNA helicase is a crucial enzyme that plays an essential role in various cellular processes involving DNA. Its primary function is to unwind the double-stranded DNA molecule, enabling the separation of two complementary strands.

The helicase function is required for efficient and accurate replication, repair, and recombination of the genome. Similarly, helicase functions facilitate RNA metabolic processes such as transcription, ribosome biogenesis, translation, RNA splicing, RNA editing, RNA transport, and RNA degradation.

2025年2月5日 · DNA helicases are essential molecular motors that maintain genomic stability. These enzymes unwind double-stranded DNA, allowing access for replication and repair processes crucial to cellular function. Their activity ensures genetic information is accurately copied and repaired, preventing mutations that could lead to disease.

2025年2月14日 · DNA helicase is a crucial enzyme in molecular biology, playing an essential role in DNA replication, repair, and transcription. As a motor protein, it unwinds the double-stranded DNA (dsDNA) into single strands, enabling cellular processes that require access to …

2024年10月17日 · Helicases are enzymes essential for maintaining genetic information integrity. These molecular motors unwind DNA and RNA strands, facilitating replication, repair, transcription, and translation. Their function is indispensable to cellular life, ensuring accurate duplication and expression of genetic material.

2015年2月12日 · Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and …