HDAC3 is a Class I member of the histone deacetylase superfamily (comprising four classes based on function and DNA sequence homology) that is recruited to enhancers to modulate both the epigenome and nearby gene expression.

其中，核心是hdac1、hdac2和hdac3，这些同种型在细胞核中以多蛋白复合物的形式存在，负责去乙酰化组蛋白和转录调节因子，并且在生命形式中普遍存在。接下来是hdac6，负责细胞质蛋白的去乙酰化。

2024年12月25日 · HDAC3 (Histone Deacetylase 3) is a Protein Coding gene. Diseases associated with HDAC3 include Retinoblastoma and Acute Promyelocytic Leukemia . Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Transcriptional Regulation by MECP2 .

2023年4月18日 · In this review, we comprehensively summarize the knowledge of the relationship of HDAC3 with mitochondria function and metabolism, ROS-produced enzymes, antioxidant enzymes, and oxidative stress...

组蛋白去乙酰化酶(histone deacetylase,HDAC)是一类蛋白酶,对染色体的结构修饰和基因表达调控发挥着重要的作用。一般情况下,组蛋白的乙酰化有利于DNA与组蛋白八聚体的解离，核小体结构松弛，从而使各种转录因子和协同转录因子能与DNA结合位点特异性结合，激活基因的转录。

大量证据表明hdac在先天免疫中发挥重要作用，一些研究已将特定的hdac酶与骨髓发育联系起来。在人单核细胞向巨噬细胞分化期间，hdac5被上调。另外，通过与转录因子pu.1相互作用并阻断靶基因的表达，hdac3负调节骨髓细胞分化。

2021年7月23日 · In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.

1.HDAC3促进急慢性Caspase-1依赖性炎症. 研究人员通过构建HDAC3髓系条件性敲除小鼠(LysM-Cre-HDAC3)，发现这些小鼠在脓毒症模型中血清炎症因子水平，腹腔及脾脏巨噬细胞caspase-1活化等指标上均显著下降并有更好的生存率。

We discovered XZ9002, a first-in-class HDAC3-specific PROTAC that potently degraded HDAC3. Importantly, XZ9002 is more effective to inhibit cancer cell proliferation than its proteolysis-inactive counterpart, suggesting HDAC3 degradation is a novel and promising anticancer approach.

2021年9月6日 · 2、据不完全统计，从抑制剂的类型上，其中包含hdac6抑制剂47个、hdac1抑制剂44个、hdac2抑制剂22个、hdac3抑制剂18个、hdac8抑制剂7个、hdac11抑制剂3个、hdac4抑制剂3个、hdac10抑制剂2个。