Halofuginone is an analog of febrifugine—an alkaloid originally isolated from the plant Dichroa febrifuga. During recent years, halofuginone has attracted much attention because of its wide range of beneficial biological activities, which encompass malaria, cancer, and fibrosis-related and autoimmune diseases.

Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis in mice.

Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1 (I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis in mice.

Halofuginone (HF) inhibited the Smad3 phosphorylation which was the downstream of the transforming growth factor-β ((TGF-β)) signaling pathway, impeding the transition of fibroblasts to myofibroblasts and fibrosisalso via F-actin augmentation and nuclear factor erythroid derived 2-like 2 (Nrf2) accumulation.

2022年11月1日 · We provide a comprehensive review of the most recent anticancer studies reported for Halofuginone (HF). HF exhibits significant anticancer activity and synergistic effects in chemotherapy/radiotherapy/virus for the treatment of various cancers in vitro and in vivo.

Halofuginone (HF), as a derivative of febrifugine, an alkaloid originally isolated from the plant Dichroa febrifuga, is used for the prevention and treatment of coccidiosis and malaria in poultry. In recent years, HF has shown excellent anticancer activity and great clinical potential for treating various cancers.

6 天之前 · Here, we report that halofuginone, a Food and Drug Administration–approved anti-scleroderma and antiprotozoal drug, is a promising anti-obesity agent in preclinical mouse and pig models. Halofuginone suppressed food intake, increased energy expenditure, and resulted in weight loss in diet-induced obese mice while also alleviating insulin ...

2025年1月7日 · Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis in mice.

Halofuginone is a potent pulmonary vasodilator by activating K v channels and blocking VDCC and receptor-operated and store-operated Ca 2+ channels in PASMCs. The therapeutic effect of halofuginone on experimental PH is probably due to combination of its vasodilator effects, via …

2020年12月1日 · Halofuginone, a natural quinazolinone alkaloid, has been shown to possess anti-fibrosis, anti-cancer, and immunomodulatory properties. However, the effect of halofuginone on periodontitis has never been reported.