2024年12月25日 · HTR2B (5-Hydroxytryptamine Receptor 2B) is a Protein Coding gene. Diseases associated with HTR2B include Bipolar I Disorder and Obsessive-Compulsive Disorder. Among its related pathways are GPCR downstream …

Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition. The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and …

2024年8月27日 · Title: Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer. Synergistic Interaction of 5-HT1B and 5-HT2B Receptors in Cytoplasmic Ca[2+] Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in …

2021年10月7日 · Here, we demonstrate that inhibition of serotonin (5-hydroxytryptamine [5-HT]) signaling through serotonin receptor 2B (HTR2B) in adipose tissues ameliorates insulin resistance by reducing lipolysis in visceral adipocytes.

2024年2月8日 · Our results make clear that peripheral HTR2B expression is required specifically for itch behaviors evoked by SSRIs, 5-HT, and alpha-Me-5HT. Title: Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to …

HTR2B is coupled to G(q)/G 11 G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca 2+ ions from intracellular stores, respectively (By similarity).

2015年5月4日 · We report herein that 5-HT 2B receptor deficiency confers a wide spectrum of antipsychotic-sensitive schizophrenic-like behavioral and psychopharmacological phenotypes in mice and provide first...

2013年10月16日 · HTR2B is coupled to G (q)/G 11 G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca 2+ ions from intracellular stores, respectively (By similarity).

2014年7月9日 · Compared with the structure of HTR2B, HTR1B displays a 3-angstrom outward shift at the extracellular end of helix V, resulting in a more open extended pocket that explains subtype selectivity.

HTR2B, Fig. 2 Signal transduction mediated by 5-HT2B receptors in cardiac fibroblasts to control the release of hypertrophic cytokines by interacting with AT1 receptors. Inhibitors used to determine this transduction pathway are shown (Adapted from Jaffre et al. 2009 )