2017年7月14日 · What is HTR2A? The 5-HT2A receptor, encoded by the HTR2A gene, is responsible for post-synaptic serotonin signaling and is a target for many antipsychotics and antidepressants. 1 Two single nucleotide polymorphisms (SNPs) in HTR2A, rs6311 (-1438G>A) and rs6313 (102C>T), have been studied for associations with response and side effects ...

The 5-HT 2A receptors is coded by the HTR2A gene. In humans the gene is located on chromosome 13. The gene has previously been called just HTR2 until the description of two related genes HTR2B and HTR2C. Several interesting polymorphisms have been identified for HTR2A: A-1438G , C102T , and His452Tyr . Many more polymorphisms exist for the gene.

2024年12月25日 · HTR2A (5-Hydroxytryptamine Receptor 2A) is a Protein Coding gene. Diseases associated with HTR2A include Obsessive-Compulsive Disorder and Major Depressive Disorder. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

HTR2A promotes the development of cardiac hypertrophy by activating PI3K-PDK1-AKT-mTOR signaling. Associations and interactions of the serotonin receptor genes 5-HT1A, 5-HT2A, and childhood trauma with alexithymia in two independent general-population samples.

RNA sequencing redefined the architecture of the serotonin 2A receptor gene (HTR2A), revealing novel mRNA transcript isoforms utilizing unannotated untranslated regions of the gene. Expression of these untranslated regions is modulated by common single nucleotide polymorphisms (SNPs), namely rs6311.

2025年2月8日 · Title: Fibroblast expression of neurotransmitter receptor HTR2A associates with inflammation in rheumatoid arthritis joint. Association of Serotonin Receptor Gene Polymorphisms with Regulatory and Adaptive Capacities of Medical Students.

We used functional and structural equation modeling (SEM) approaches to assess the contributions of the polymorphism (rs6311), DNA methylation and clinical variables to HTR2A expression in chronic fatigue syndrome (CFS) subjects from a population-based study.

The serotonin HTR2A receptor-mGluR2 complex triggered unique cellular responses when targeted by hallucinogenic drugs, and activation of mGluR2 abolished hallucinogen-specific signaling and behavioral responses.

2025年2月8日 · Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD).

Gene target information for HTR2A - 5-hydroxytryptamine receptor 2A (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.