Herpes simplex virus 1 (HSV-1) strain McKrae is highly virulent and relatively neuroinvasive in animal models compared with other wild-type HSV-1 strains. To identify the genetic determinants that lead to the unique phenotypes of the McKrae strain, we sequenced its genome with PacBio single-molecule real-time (SMRT) technology and resolved the ...

Herpes simplex virus 1 (HSV-1) has a double-stranded linear DNA genome that is approximately 152 kbp in length. Both the replicating DNA and encapsidated viral genomes contain nicks and gaps (1 – 8). In DNA isolated from virions, gaps have been reported to number 3 to 13 per genome (9, 10).

2023年8月28日 · Herpes simplex virus type 1 (HSV-1) is a linear dsDNA virus that is a member of the Alphaherpesviridae subfamily. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa.

2020年4月27日 · Herpes simplex virus 1 (HSV-1) is the causative agent of the common cold sores but also responsible for severe, life-threatening disease including generalized skin infections, pneumonia,...

2022年8月25日 · The HSV-1 genome is a single, linear molecule of double-stranded DNA approximately 152,000 bp in length. It is divided into two unique segments called long (U L ) and short (U S ). Short regions of repeated sequence (a/b/c and a’/b’/ c’) occur at the genome ends and between the L and S segments.

Herpes simplex virus 1 (HSV-1) is a human pathogen that leads to recurrent facial-oral lesions. Its 152-kb genome is organized in two covalently linked segments, each composed of a unique sequence flanked by inverted repeats.

The HSV-1 genome is a 153-kilobase linear duplex with 75 open reading frames. It consists of two unique regions, U L (unique long), comprising 82% and the U S (unique short) comprising 18%, flanked by the repeated regions a, b, and c (Fig. 1).

The objectives of this paper are to discuss the structure and genetic content of the genome of herpes simplex virus type 1 (HSV-1), the nature of virus DNA replicative processes, and aspects of the evolution of the virus DNA, in particular those bearing on DNA replication.

2019年9月12日 · Herpes simplex virus type 1 (HSV-1) strain MacIntyre has a severe defect in the anterograde spread after replication in the nucleus. To better understand and identify the genetic determinants that lead to the unique phenotypes of the MacIntyre strain, we sequenced its genome with PacBio single-molec …

Genotyping of HSV-1 is currently based on analyses of intragenic sequence polymorphisms of US2, glycoprotein G (gG, US4) and gI (US7). Each of the 10 German HSV-1 isolates displayed a different US2/gG/gI-genotype combination, but clustered either in phylogroup I or II.