2024年12月25日 · HOXB4 (Homeobox B4) is a Protein Coding gene. Diseases associated with HOXB4 include Leukemia and Sickle Cell Disease. Among its related pathways are RNA …

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene. [5][6][7] This gene is a member of the Antp homeobox family and encodes a nuclear protein with a …

2021年1月21日 · Homeobox B4 (HOXB4), which belongs to the homeobox (HOX) family, possesses transcription factor activity and has a crucial role in stem cell self-renewal and …

2002年4月5日 · Here we demonstrate the potency of HOXB4 to enable high-level ex vivo HSC expansion. Cultures of nontransduced or GFP-transduced murine bone marrow cells …

2002年4月5日 · Hox transcription factors have emerged as important regulators of primitive hematopoietic cell proliferation and differentiation. In particular, HOXB4 appears to be a strong …

HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/beta-catenin signaling pathway. HOXB4 promotes the malignant progression of …

2007年10月23日 · HOXB4 mediates expansion of adult and embryo-derived hematopoietic stem cells (HSCs) when expressed ectopically. To define the underlying molecular mechanisms, we …

Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. …

2021年1月21日 · Homeobox B4 (HOXB4), which belongs to the homeobox (HOX) family, possesses transcription factor activity and has a crucial role in stem cell self-renewal and …

HOXB4 silencing enhanced the cytotoxic effect of Taxol and DDP by downregulating ABC transporters via inhibition of the PI3K/Akt signaling pathway. These results for the first time …